<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00205

Description Mediator of RNA polymerase II transcription subunit
SequenceMMGILYEKRPLKRPRLGPPDVYPQEPKQKEDELSLTNVKHGFTTIPQLADEFGTARSSNVTAAKVGAYFNAILAKKEELATMPDTGRKRQQINPKDNFWPVTARTKNGIEAWFKDLSGSKPLVALAKKAPNFNKKEEIFMMLCEYQVPMLRAAWFIKLSSAYTVAVSEAKIKKRQLPDPTTEWTGTLIKFLKDQLSKLQEYYHMGNHAASTGNNNSTTNSSCNSSNGTAGTNNSNNNSNSSNNNSVNGNNASNSNGSATNNQPPTPTLSSQPATGTTMNEEHKLALKQWHYCIQLAKYMFEEGLLDRQELLQWILELLDKIRSSPSEDGILKLLLPLALQYLEEFIQSELLARRLAYLCCRKMAHMCNNVESNANPQSPSIVKNEVNGSKEQAAVAAQGPLNPLIIAFNDYLTCSHHRDVVYSLATIIQVITLECPTALVWNSVGEGKAPSVLNGSPLDYLPCPPAALPCPPASSGNPTMKQLKVAQENIRARSQAAEGRWSCDKWQQSSAGTTTTKVLAALDALDRHSFDRMDAANSLDTLYTKIFTPPPKDTSNERDAKTEYNPQQDSAVVEILCEWAVSAERWGEHRAMAVAKLLEKRQSEATGETNDNDDKDSMCSNGSPPVLPIFQPLLMKFLDVDAPVLDNTSTQSKAQFTNLVHLFSELIRHDVFSHDAYMCTLISRGDLIQGPVASKPGTPSNREPIDEDSLFPGIDLKPTKLEVSDHGRAMDYDDSKIDDDLDKLLQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPSSHSRHLLYTTHFPLPQDETCSQHDCNQRHVLLYGVGRVRDEARHTVKKMTKEVCKLFGKKFSIDVAEGGKVKKHSRSEFNFEAVTMKFQNLSYFDQHVVTWQCATQVIEMLNTFALAGSSYLPVHEHVAFLFDLMELALNIYGLIDVCIQILKELPEVEAQLTARNSQLVRSYTTNLSLYVVGVLRRYHCCLLLSPEQTTAVFDLLCKVVKHVSNPSDCSSAERCVLAHLYDLYSTCSLLKTKSHGVEAFSNAYPKIRTTLYSTLQPTPSSHVYNSQFMVDIFSSLRRGGKIEPQWARQLNETPANRYSFVCNAIVAVCSETDNDKLNDVAITCAELTACCNTLNAEWLGVLMALCCSSNSSAFYIDVLNQVDVQDLSIHNSLAIFTSILIARHCFSLEDFVVHIALPSLVKTCNDGRGDIDIEAEAGARLTCHLLLRLFKTVECPQPALYSVSTSPHPLPSGNSRGYSIKLSCDRHLLAAAHNNIRVGPVLAVLKAILVVGDAAAAKQPPKKVDIPLSHSSKGGGPASVGVGVGVSSSGPGELSISHILGTSDILGGGDDLGLDLAMSSSNSSAGMTTENVKGFSDFAHHVLRQICSQEWVLERCLQNPEELCHQDMLLDNMLTLRQAQKLLHMICYPETPTEAFIDQKTHITNILENLEQWSLRMSWLDLQLMYKQFSPGSSELSQWLDTVAKAAIDVFQLNSILNSKPDKRSGSIWLVAPLVSKLPSAVQGRVLKVAGQVLESGNWSKTAGRERGKSKSPSLFNHQPFLSLVLTCLKGQDDQREGLLTSLHSQLSQFLNTSKEEKHIGSEDPKTREVLQDALQLRFSLVGGVFDTIQRNTTATTDWAILLVQLVSYGVIDLNNNSELFTTVIDMLATLIHSTLVSDSQSEKDENKKHYQNLMKKLKKELGDRNSPSIRFVRQLLPLPKLTMEVITCEPVGCLTDTKGNKIAGFDSIDKKQGLQVCDSQRVSAWELLEGHKNPAPLSWAWFRAVRLERRPLTYQNAHKLLRYHTHSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRISSNVTNTGVSNAGTNGKGKAMKSKRHNRRTKGPATPTTPISQQMQQPPSQLQQMAFANQQAPVAQQPGMFTGQPQPQPQQQWYGNQTHVPAQQYGYGQQLPPTPVTGPRYERPGMNNQSKQALSNMLRLRLPSTQFMGSQQQPTAAPVAGPGAFQGMQRQQFIRQQLRAQHGAPGMNQQQGMFAQTQQQQQQQQQGMYAGIQQGMNQNYAGYGGQQMMQQQQQQQQQTPQQTQQQQQQQLLQQQQQQQGILNQQQQNMMFSNQQQMMGPQREYMPQQRMQPGAARPPYLQAPNVTMNAMGPMGGGVQNQPAPPYRQSAGKPGAVGVAGVGTTNVSLQQNQQFQQQQAINQQRMRQQMLAMQQQQQAQQQQQQAAQQQGGASNQLLRHLNQPPQHSYQHQPPPY
Length2246
PositionKinase
OrganismOoceraea biroi (Clonal raider ant) (Cerapachys biroi)
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Arthropoda> Hexapoda> Insecta> Pterygota> Neoptera> Endopterygota> Hymenoptera> Apocrita> Aculeata> Formicoidea> Formicidae> Dorylinae> Ooceraea.
Aromaticity0.06
Grand average of hydropathy-0.500
Instability index50.51
Isoelectric point7.53
Molecular weight249169.41
Publications
PubMed=24508170
PubMed=30249741

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00205
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             5|     158.95|      21|      22|    2179|    2199|       1
---------------------------------------------------------------------------
 2028- 2046 (33.06/10.47)	Q...TQQQ.QQ.QQQQGM.YAGIQQ
 2047- 2068 (30.24/ 8.98)	G...MNQNyAGYGGQQMMQQQQQQQ
 2069- 2091 (32.40/10.12)	Q.qtPQQT.QQQQQQQLLQQQQQQQ
 2179- 2198 (32.67/10.26)	....LQQN.QQFQQQQAINQQRMRQ
 2199- 2219 (30.58/ 9.16)	QmlaMQQQ.QQAQQQQ...QQAAQQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.09|      18|      23|     770|     790|       2
---------------------------------------------------------------------------
  770-  790 (29.92/27.90)	HGgheSL.DSKMPSSH...SRH.LLY
  793-  815 (23.16/11.51)	HF...PLpQDETCSQHdcnQRHvLLY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     146.36|      21|      24|    1882|    1902|       4
---------------------------------------------------------------------------
 1893- 1919 (21.43/ 6.01)	QLQQM...AF..ANQ....qaPVAQQpgmfTGQPQ...P
 1920- 1946 (26.54/ 9.57)	QPQQQ...WY..GNQthvpaqQYGYG....QQLPP...T
 1947- 1967 (22.64/ 6.85)	PVTGP...RY..ERP......GMNNQ....SKQAL...S
 1996- 2019 (24.53/ 8.17)	AFQGMqrqQF..IRQ......QLRAQ....HGAPG...M
 2097- 2117 (25.67/ 8.96)	QQQNM...MF..SNQ......Q...Q....MMGPQreyM
 2118- 2137 (25.56/ 8.89)	PQQRM...QPgaARP......PY.......LQAPN...V
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      65.76|      15|      15|    1303|    1317|       5
---------------------------------------------------------------------------
 1287- 1301 (18.38/ 8.37)	AAAKQPPKKVDIPLS
 1303- 1317 (25.87/15.56)	SSKGGGPASVGVGVG
 1319- 1333 (21.50/11.36)	SSSGPGELSISHILG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      68.53|      15|      15|     327|     341|       6
---------------------------------------------------------------------------
  301-  317 (20.16/10.74)	EEGLLdrQELLQWILEL
  327-  341 (24.31/14.67)	EDGIL..KLLLPLALQY
  343-  357 (24.06/14.43)	EEFIQ..SELLARRLAY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.41|      13|      15|    1377|    1389|       7
---------------------------------------------------------------------------
 1377- 1389 (26.03/18.21)	QICSQEWVLERCL
 1394- 1406 (23.38/15.42)	ELCHQDMLLDNML
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.87|      13|      15|     989|    1002|       8
---------------------------------------------------------------------------
  989- 1002 (21.86/19.88)	CkVVKHVSN.PSDCS
 1007- 1020 (22.02/13.92)	C.VLAHLYDlYSTCS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.49|      13|      15|    1122|    1134|       9
---------------------------------------------------------------------------
 1122- 1134 (26.11/17.62)	CCNT.LNAEWLGVL
 1138- 1151 (20.38/11.93)	CCSSnSSAFYIDVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      55.44|      16|      19|     522|     540|      10
---------------------------------------------------------------------------
  497-  512 (31.70/15.72)	AEGRWSCDKWQ.QSSAG
  524-  540 (23.74/13.33)	ALDRHSFDRMDaANSLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.08|      11|      19|    1443|    1453|      11
---------------------------------------------------------------------------
 1443- 1453 (23.79/12.86)	EQWSLRMS....WLD
 1459- 1473 (17.29/ 7.31)	KQFSPGSSelsqWLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      89.28|      29|      46|      46|      80|      12
---------------------------------------------------------------------------
   46-   80 (39.63/48.31)	PQlaDEFG..TARSSNvtaaKVGAYFNAILAKKEELA
   94-  124 (49.65/38.98)	PK..DNFWpvTARTKN....GIEAWFKDLSGSKPLVA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.12|      17|      23|     725|     741|      13
---------------------------------------------------------------------------
  725-  741 (31.86/21.48)	DHGRAMDYDDSKIDDDL
  751-  767 (31.26/20.92)	DQQNSMDAPDSPKEDAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      35.04|      10|      20|    1233|    1242|      14
---------------------------------------------------------------------------
 1233- 1242 (19.88/10.41)	YSV..STSPHPL
 1250- 1261 (15.16/ 6.11)	YSIklSCDRHLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.62|      11|      22|    2141|    2151|      15
---------------------------------------------------------------------------
 2141- 2151 (22.40/14.72)	AMGPMGGGVQN
 2166- 2176 (19.23/11.41)	AVGVAGVGTTN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      41.13|      13|      17|    1498|    1512|      22
---------------------------------------------------------------------------
 1498- 1512 (19.50/15.73)	GSIWLVAPLVskLPS
 1516- 1528 (21.64/10.85)	GRVLKVAGQV..LES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00205 with Med12 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) LDKLLQHIKEDQQNSMDAPDSPKEDALTGHGGHESLDSKMPS
2) THSQIRPASHYLDPPPLPPEDLEPDKKESEPGKADTPMSIDSPGRISSNVTNTGVSNAGTNGKGKAMKSKRHNRRTKGPATPTTPISQQMQQPPSQLQQMAFANQQAPVAQQPGMFTGQPQPQPQQQWYGNQTHVPAQQYGYGQQLPPTPVTGPRYERPGMNNQSKQALSNMLRLRLPSTQFMGSQQQPTAAPVAGPGAFQGMQRQQFIRQQLRAQHGAPGMNQQQGMFAQTQQQQQQQQQGMYAGIQQGMN
3) YAGYGGQQMMQQQQQQQQQTPQQTQQQQQQQLLQQQQQQQGILNQQQQNMMFSNQQQMMGPQREYMPQQRMQPGAARPPYLQAPNVTMNAMGPMGGGVQNQPAPPYRQSAGKPGAVGVAGVGTTNVSLQQNQQFQQQQAINQQRMRQQMLAMQQQQQAQQQQQQAAQQQGGASNQLLRHLNQPPQHSYQHQPPPY
4) YHMGNHAASTGNNNSTTNSSCNSSNGTAGTNNSNNNSNSSNNNSVNGNNASNSNGSATNNQPPTPTLSSQPATGTTMNE
741
1798
2052
202
782
2049
2246
280










Molecular Recognition Features






MoRF SequenceStartStop




1) ASNQLLRHLN
2) MLRLRL
3) MMGILYEKRPLKRPRLG
2223
1969
1
2232
1974
17