<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00200

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMNPMMPPDPADLKGLTSRCIDRSYDSLYNLTTSLPNTPSEERRDVALKQLHDTYATFKKLLVLTRWSVQSPLTDKCAELLQEAQTFQDQANETNDRLYFLHRDLDRAKERKYDLTTAIDVLYGGTYNRLPRVINYAMHPREFPPVDEEASIAELDAVLRFRLIEETIPDKFTDINVQDGFVTAHAAGEFDMVFTVDGTKPESLWLVASVHTVLTDPTALATYKHLASTSSLRIIQSNAPTDTHYMQLKILIQKRLNHSTTPLLDACNIMADFCCSLALRILDAQGQLLVETRWPHGVSFVNHDDVNTLDIVYWTDNNTTLPYVQSSAPGTFSIEEMRTRMHPDSLAYPTNGCSLRLQPRMGGDSPGLFSLQLFPAPPAALLKRYPTLLDRALAVPANLFSLSADHFLLGSMQVHAASALFCLERHLLVDDKTVVIEGTYSEQRLTTGTAVLVARSPRTLRLSRVDSTGCTPLEVSWDLRTGRFGVFCLAKAPSVVVAVRHLEILLQTRCKVQLPGVTVAGELSLTFLTQNTDSDKTTVTNDASEVVAAVAAVLRQVVASELVTFASSCSNMHVARVRDRHAAAIDSLGLSPDAIFVQLVRSKDAAVFLVVELDRFSQDDDAPQRPLRRRHVGSLDLVDEDDEYIRSPVFSVVQLADRSALASTTSVRFFERLPVVRRTDVFAGSGTSFGSRKRKRRDLPFLSALLVHMAALGHQRAHWHAIDAFARKYNASLTTSTTLSRCKQFTDSTVDGALDSRALLPSRPSSIVAVSIPFPDRIQTNPQLAIHSLEARLVCIHGSTASSTAEITMRVAAPPFAYVLLAPTLASHVPTMRGRSFTCAARPNGDLVYQSSSTNHKFQANLIDVVVANVMLHVKPMADLGRRLERTLGALMRYRSAPAGHFYAERADPFKFTLACQTHENAVARIHIEHKVVHQFPRGAFVLTSSPHHVLLPFLQDAFNSHKSSAQLLEVLERTTVPLTMLSRAMAAHSAAKTTLTGSSAEAGLENPYPTFVPSNLVLVPRSQTHLRLTYGDRCAVDVIFLADHQIKIQCAPASLVPVPSYSKPGGATVDRAAFYDTLRLSLFPEMAAV
Length1089
PositionTail
OrganismAphanomyces invadans
KingdomOomycetes
LineageEukaryota> Sar> Stramenopiles> Oomycota> Saprolegniales> Saprolegniaceae> Aphanomyces.
Aromaticity0.07
Grand average of hydropathy-0.062
Instability index48.28
Isoelectric point7.44
Molecular weight120245.06
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00200
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.12|      21|      44|     827|     850|       1
---------------------------------------------------------------------------
  827-  850 (35.93/34.74)	HVPTMR..GRSFtcaARPNGDLV.YQS
  872-  895 (30.19/19.02)	HVKPMAdlGRRL...ERTLGALMrYRS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     224.22|      74|      90|     153|     239|       2
---------------------------------------------------------------------------
  153-  239 (113.46/88.55)	ELDAVLRFRLIEETIPdkFTDI.NVQDGFVTAHAAGEFDM..VFTVDGTKPESLWLVA..SVHTV....LTDPTALATYkhlastsslriIQSNAP
  246-  328 (110.76/64.00)	QLKILIQKRLNHSTTP..LLDAcNIMADFCCSLALRILDAqgQLLVETRWPHGVSFVNhdDVNTLdivyWTDNNTTLPY...........VQSSAP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     270.34|      92|     252|     698|     798|       3
---------------------------------------------------------------------------
  698-  798 (142.79/106.03)	LPFL.SALLVH..MAALGH..QRAHWhAIDAFARKYNASLTTSTTLsrckqfTDSTVDGALDS..RALLPSR....PSSIVAVSIPFPDRIQTNPQ.LAIHSLeaRLVCIHGS
  951- 1054 (127.55/74.13)	LPFLqDAFNSHksSAQLLEvlERTTV.PLTMLSRAMAAHSAAKTTL......TGSSAEAGLENpyPTFVPSNlvlvPRSQTHLRLTYGDRCAVDVIfLADHQI..KIQCAPAS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.30|      10|      46|     345|     354|       4
---------------------------------------------------------------------------
  345-  354 (20.33/12.57)	LAYPTNGCSL
  392-  401 (16.98/ 9.13)	LAVPANLFSL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      38.29|      13|      42|     599|     614|       6
---------------------------------------------------------------------------
  599-  614 (17.95/17.84)	VRSkdaAVFLVVEL.DR
  644-  657 (20.34/10.78)	IRS...PVFSVVQLaDR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      43.10|      13|      97|      15|      35|      10
---------------------------------------------------------------------------
   20-   35 (19.62/29.80)	IDRSYDSLYNlttSLP
  118-  130 (23.48/ 8.17)	IDVLYGGTYN...RLP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00200 with Med14 domain of Kingdom Oomycetes
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