<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00129

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMAEVGQETLDFAALVGRAAEESYVSLKELVEKSKSTEMLSDADKKIMILKYIVKTQQRMLRLNVLAKWCQQVPLIQYCQQLASTLSSHETCFSQAADSMFFMHEGLQQARAPIYDVPSAIEVLLTGSYQRLPKCIEDVGTQSILNKDQQGPALKKLDTLVRSKLLEVSLPKEFTGIEVSDGVVLVRVDGEFKVLVTLGYRGHLSMWRILHLELLVGERSGLVKVEESRRHALGDDLERRMAASENPFTTLYSILHELCVALIMDTVIRQVQTLRQGRWKDAIRFELISDGTTGQGGSASSSHGTHDGDTDSGLRTPGLKIIYWLNLDKSTGTSDSGISPFLRIEPRPDLQIKCSHSTFVIDPLTDKEADFTLDRSCIDVEMLLLRAIGCNRYTRLLEIYKEVEKNGQINRTPGDVQLQFHLDDFATDCGKRDNDALDQKHDGQEVLHVRAYGSSFFTLGINIRSGRFLLRSSKNIISSKALLECEEALNQGSITAAKAFINLRKNSILHLFASIGRFLGLEVFDHGFTAAKLPKNISDESNSLFMGFPECGSSYFLLMQLDKEFKPCPKLIEAQTDPSGKGEAFGDMSKVTRVKDLDISTMHMCKDELSLSLLDRRKMVSILDDVNVNEVSERILHSNSSLEGSVARSSVPISFSSIVDEVFEIEKGSSGHNTLSTSGLSSTSRFGLGSMNLHNAKPSASPQNWDGAQTLQNSVSNFKSLMPSGSTSSLTTPSVKSQAMNKLTASKSDQDLSALRSPHSGRFGSYGVMDEDQLTVAGLPSARLLSPPQRTGPPVSVNSNQESIPQHDGIPRKRTVSDMLKSIPSLHCLAINEASNKRRKIKETPHAELSHTPPLSSCDHPCKIEKHSFANLIAEANMGSASPSIYVSALLHIVRHCSLCIKHARLTSQMEELDIPYVEEVGLRSASSNLWFRLPFSRDDTWQHICLRLGSPGSLYWDVKIVDPHYEDLWELQNGSNTTPWGSGIRIANTSDVDSHIRYDSEGVILSYNSVEADSIKKLVADIQRLSNAKTFALGMRKLLGARTDEKLEENNGNLDSKNPAGLKTVMEGYEKLSEQMRRAFRIEAVGLMSLWFSFGSGVLARFVVEWESGKEGCRMHVSPDQLWPHTKFLEDFINGGEVESLLDCIRLTAGPLHALAAATRPARAAPVSGVPGMTSSISSTLKQTGYVPSQSLPSNSNTNTSQASSGPAGNPGVPTSTGPIGTHNTAAVLAAAAAAAAAAAAGRGGPGPGIVPSSLLPIDVSVVLRGPYWIRVIYRKNFAVDMRCFAGDQVWLQPATPPKVGAPIGGSLPCPQFRPFIMEHVAQELNGIDSNFPGATQALGLSNSNNPNQSATSQLPVTPGSRSNLANTSPMARTGNVLAVLNRTGNSLPGSSNVPLVNQLRRSPSSAVPAHVRGELNTAIIGLGDDGGYGGGWVPLVALKKVLRGILKYLGVLWLFAQLPELLKEILGSILKDNEGALLNLDQEQPALRFFVGGYVFAVSVHRVQLLLQVLSVKRFQPTQQQQNSATALEELTQSEIGEICDYFSRRVASEPYDASRVASFITLLTLPISVLREFLKLIAWKKGLTQGQGAATAADSASPTQKSRIELCLENHMGFNKDGIADNTSSVSKSNIHYERAHNSVDFGLTVVLDPAHIPHINAAGGAAWLPYCVSVRLRYSFGENNPTVSFLRMEGSHGGRACWLRSDEWDKCKQRVIRTVEVNGSSSGGDNNNTNTNNNTNQGRLRVVADSVQRTLHACLQGLRDGIGMT
Length1768
PositionTail
OrganismErythranthe guttata (Yellow monkey flower) (Mimulus guttatus)
KingdomViridiplantae
LineageEukaryota> Viridiplantae> Streptophyta> Embryophyta> Tracheophyta> Spermatophyta> Magnoliopsida> eudicotyledons> Gunneridae> Pentapetalae> asterids> lamiids> Lamiales> Phrymaceae> Erythranthe.
Aromaticity0.06
Grand average of hydropathy-0.227
Instability index44.09
Isoelectric point6.94
Molecular weight192799.75
Publications
PubMed=24225854

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
core mediator complex	GO:0070847	IBA:GO_Central
mediator complex	GO:0016592	IBA:GO_Central

GO - Biological Function
transcription coregulator activity	GO:0003712	IBA:GO_Central

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IBA:GO_Central









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00129
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     214.66|      44|      67|    1150|    1193|       1
---------------------------------------------------------------------------
 1150- 1193 (79.34/47.65)	GPL..HA....LAAATRPARAA....PVS.G...VPGMTSSISST..LKQ..TGY...V......P..SQSLP
 1218- 1257 (42.88/21.97)	GPIgtHNtaavLAAAAAAAAAA....AAGrG...GPG...............PGI...V......P..SSLLP
 1287- 1339 (53.76/29.63)	GDQ..VW....LQPATPPKVGA....PIG.GslpCPQFRPFIMEH..VAQelNGIdsnF......PgaTQAL.
 1341- 1389 (38.68/19.00)	...........LSNSNNPNQSAtsqlPVT......PGSRSNLANTspMAR..TGN...VlavlnrT..GNSLP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     837.34|     268|     293|     463|     751|       2
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  216-  303 (50.27/20.88)	.GERSGLVKVEE...SRRHALGDDLERRMAASENpfttLYSILHELCVALIMDTVIRQVQT.............LRQ..GRWKDAIRF...ELISD.......GTTGQ......GGSASSSHG...............................................................................................................................................................................................................................................................................................................................................................................................
  463-  583 (89.78/80.87)	................................................................................................................................................................................................thdgdtdsglrtpglkiiywlnldkstgtsdsgispflrieprpdlqikcshstfvidpltdkeadftldrscidvemlllraigcnrytrlleiykevekngqinrtpgdvqlqfhlddfatdcgkrdndaldqkhdgqevlhvraygssfftlginiRSGRFllrSS.........KNIISSKAL....LECEEALNQGSITAAKAFINL............RKNSILHLFASIG.....RFLGLEVFDHGFTAAKLpKNIS.DE..SNSLFM.GFPECGSSYFLLmqldkefKPCPklIEAQTDPSGKGEA
  584-  875 (385.23/277.22)	FGDMSKVTRVKDLdiSTMHMCKDELSLSLLDRRK....MVSILDDVNVNEVSERILHSNSS.............LEGSVARSSVPISF...SSIVDEVFEiekGSSGHNTLSTSGLSSTSRFGLGsMNLHNAKPSASPQNWD..GAQTLQNSV..SNFKSLMpsGSTSSLTTPSVKSQAMNKLTASKSDQDL.........................................................................................................................................................salrspHSGRF...GS.........YGVMDEDQLtvagLPSARLLSPPQRTGPPVSVNSnqesipqhdgipRKRTVSDMLKSIP.....SLHCLAINEASNKRRKI.KETP.HA..ELSHTP.PLSSCD.............HPCK..IEKHSFANLIAEA
  877- 1142 (312.05/201.77)	MGSASPSIYVSAL....LHIVR.HCSLCIKHAR.....LTSQMEELDIPYVEEVGLRSASSnlwfrlpfsrddtWQHICLRLGSPGSLywdVKIVDPHYE........DLWELQNGSNTTPWGSG.IRIANTSDVDSHIRYDseGVILSYNSVeaDSIKKLV..ADIQRLSNAKTFALGMRKLLGARTDEKL.........................................................................................................................................................................eenngnldsKNPAGLKTV....MEGYEKLSE...QMRRAF.RI............EAVGLMSLWFSFGsgvlaRFV.VE.WESGKEGCRM..HVSpDQlwPHTKFLeDFINGGEVESLL..........................
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     101.05|      33|      65|    1507|    1541|       4
---------------------------------------------------------------------------
 1507- 1541 (49.94/35.42)	LLQVLSVKRfqPTQQQQNSATALEEL..TQSEIGEIC
 1575- 1609 (51.11/29.79)	FLKLIAWKK..GLTQGQGAATAADSAspTQKSRIELC
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.42|      20|      22|    1433|    1453|       6
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 1429- 1448 (37.33/24.35)	Y.GGGWV..PLVA.LKKVLRGILK
 1449- 1472 (23.09/17.14)	YlGVLWLfaQLPElLKEILGSILK
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00129 with Med14 domain of Kingdom Viridiplantae
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