<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00109

Description Mediator of RNA polymerase II transcription subunit 20
SequenceMPITGVFFIPSNPNASTVLSTISERLHTVLTDEPIPVGRWVLEHKLMRDTPSCLPASASQRPAQPRWMQFLSLSYHPFHGFVYASEADKSQFGGVAQAQPQSQAQAPGAAPKASPQQPQPQQQPQLSTSTSTATSTNSGMIMTTVPLPSSVTLFQHFVYACQPFWSHRHTHTIPGGMVYDIGDFRVRIGDVRQTQPVARIRGTVVEVEWRGPSLLDSLVQSHPVTEMQDNGADDGDSGIDVGLELIEEADVDAEFAATAKLIREFWEKLGVEGAREAILVPDVGKEVKEQLRRWKALQQEGKKDVGRGVGEGNGQLLDEDPDPQAGVDVARQFMEIFRFNR
Length341
PositionHead
OrganismAspergillus ruber CBS 135680
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.399
Instability index47.96
Isoelectric point5.31
Molecular weight37518.73
Publications
PubMed=24811710

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364152
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00109
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.70|      21|      25|     266|     290|       1
---------------------------------------------------------------------------
  242-  260 (14.45/ 6.13)	....GLELIEEA....DVDAEfaATAK
  266-  290 (31.75/33.85)	WEKLGVEGAREAilvpDVGKE..VKEQ
  294-  311 (27.49/18.10)	WKALQQEGKK......DVGRG..VGE.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     121.87|      24|      93|      77|     100|       2
---------------------------------------------------------------------------
   77-  100 (43.83/27.92)	PFHGFVYASEADKSQFGGVAQAQP
  154-  174 (38.61/23.77)	.FQHFVYACQPFWSHRH..THTIP
  175-  196 (39.42/24.41)	G..GMVYDIGDFRVRIGDVRQTQP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.70|      20|      98|     121|     140|       4
---------------------------------------------------------------------------
  101-  120 (35.05/17.25)	QSQAQAPGAAPKASPQQPQP
  121-  140 (32.65/15.65)	QQQPQLSTSTSTATSTNSGM
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00109 with Med20 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) FGGVAQAQPQSQAQAPGAAPKASPQQPQPQQQPQLSTSTSTATSTNSGMIM
92
142










Molecular Recognition Features






MoRF SequenceStartStop




1) RQFMEIFRFNR
331
341