<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00105

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMVITTTAPSPSSAKQWKLFFDQCLKHRIDANEFKNLSNILAARCSVSESVLVDVLCDVRAVGAAAGVKWDPLVPVYIDCLCKTERVKISSVLAGLLKRSSILLQSQSQIQSSDESDKSKQRKKNGYTLMTDIRAIQDVMLAVSTGNNTPRTSAEAIDIFSAAVDWIQAVVSWHQQHQQTGGLMGSPDAVSLFESLGILLAALSGTTKGVDVLSSDHEGLKIKLGQALSAYLPLCVEVSLPLRNRLDSLQKEFSLYGEPASKSLDMAMVEGMNVNALQFEASVMDGPVINSRAGLYVYINSMLVGRPLIDDNMLLSYLVNRYGGHYKALIEEVITASFDVLSNAMYRNESNRTMFIFRSFLVNKLPAFFATMLAASMVTIPMEICISNALGRLDPNTFPSFSQMFSMQGNTVLSDVRQEFLFACASHRLIPESSIERLLGENPMQAVPVGHVKDDLVSQIYANPERAEQLINDIESTEGNANAIVGAITEVIHQLCNQKESMTLKNICISLSRRPQALDVILLFRSTKQILQPLCTLLDNWHWDSDQGENQPVYDEFGSILLLILNFKYRYDLKPYELGISSDDSFVLKLLDRGSCNQKLEDLTEKQNKDLGAWIGALFIAEGISEETMSNCSPQEFYLLVTTLFSQSLGACEAGKLEFETLKGGFEYLLEPFLLPSLVVALGWLGNRIWESESEPTIALKTLHSLVSPTSISGEAQAIHQTVISMTARTLEEQLKDVRARHPSRTDIKPILDALEPHLSFQRTGSCHRTELESWSHSGNGSVGGLLGSVRNTFQSLVLWSTNPEISMAPPSYTHRQVVAGVRMLGATRVLRALEEELKLQTEAGSGDLALDVAAMIVSAPMMESFTADQMHYHPPENKDQSQQSKHQQTATNLRSPVLTLRDALSIRHQDVPRISEKDPLRAEMIVRLYRRVNAVTAPTAQVPSLDVSNILGNMSVTDQSSQPQARSQSQTQQQSQQQQQAQQQAQSQEQQQPSQMDLDADAENGDFSHMLDTAAAAAGNGGGDMDGMDMGTGLDTSIDDVLNAADIAAVGNPEFLDLDMEGMF
Length1064
PositionTail
OrganismAspergillus ruber CBS 135680
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.06
Grand average of hydropathy-0.147
Instability index50.25
Isoelectric point4.98
Molecular weight117015.63
Publications
PubMed=24811710

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	ARBA:ARBA00003669
ECO:0000256	RuleBase:RU364142
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00105
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      70.60|      24|      29|     997|    1020|       1
---------------------------------------------------------------------------
  997- 1020 (43.86/28.97)	DLDA.DAENG.DFS..HMLDTAAAAA.GN
 1024- 1052 (26.74/14.62)	DMDGmDMGTGlDTSidDVLNAADIAAvGN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      37.82|      10|      29|     959|     968|       2
---------------------------------------------------------------------------
  959-  968 (18.89/ 8.49)	QSSQPQARSQ
  986-  995 (18.94/ 8.54)	QSQEQQQPSQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      76.39|      20|      29|     637|     662|       4
---------------------------------------------------------------------------
  637-  656 (34.47/16.43)	YLLVTTLFSQSLGACEAGKL
  667-  677 (13.28/ 8.09)	YLLEPFLL.PSL........
  754-  771 (28.64/14.86)	..LEPHLSFQRTGSCHRTEL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      47.12|      12|      20|     885|     904|       7
---------------------------------------------------------------------------
  175-  186 (24.41/ 7.62)	QHQQTGGLMGSP
  885-  896 (22.71/ 6.13)	KHQQTATNLRSP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.64|      18|      28|     455|     475|       8
---------------------------------------------------------------------------
  455-  475 (25.06/23.36)	LVSQIyanPERAEQLINDIES
  483-  500 (31.58/19.47)	IVGAI...TEVIHQLCNQKES
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00105 with Med5 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) APTAQVPSLDVSNILGNMSVTDQSSQPQARSQSQTQQQSQQQQQAQQQAQSQEQQQPSQMDLDADAENGDFSHMLDTAAAAAGNGGGDMDGMDMGTGLDTSIDDVLNAADIAAVGNPEFLDLDMEGM
2) FTADQMHYHPPENKDQSQQSKHQQTATNLRSPVLTLRD
937
865
1063
902










Molecular Recognition Features






MoRF SequenceStartStop




NANANA