<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00097
Description |
Mediator of RNA polymerase II transcription subunit 17 |
Sequence | MSSDAPDDSSATTDSFTLPLRPLIEKRDRPDTLPVEIAQINAQWGSFRDVNEDELQVKIQEEKDKEGIEDEDEEEKPAGEVDSTERLEQLYKRRAEITQFALQAQMETMFALDFVSLLLSKHVPRQAETSMSAFLKQAVPLGSLNSEIVSPPLKPESAAQDPKVVSRGWRLQSFDAAANKLLKSASRLETEVASETRYWSEVLAVKDKGWKVSRLPRERQALGVQYGFLEATPIFRDRGLASLRRADDGSLILDKGLVPSKSRRIRVRVKINDRVTGCSKSTRSTADGEESIETRILQARDTVYEEELFHELVREARIMGGQGVTTRQNLIRFAVSEEQEIMLDLADTDLESFSEDTDVIDSHEDDVLADAIAHSTRILLSYAHRQNLHRRTQPPPPLSQKRRHTPEYQLLRPILAYLQHRSHVEWLESFIKDMYGVLKSAGVDSDYSANLFSSVNPQRKNHSLPKVEALVQGFLVPLESTISGSLITPKSPFRVRIRTSLVSPPFGTNYDISMTMPQHPGIQPPARVGLRSEAAAIITHFLMLDVVSAVSSYRPPPGVDGHLMWQAAYPHHGELLTVSPTSGEHKKKMKVTLTRGEMTLDVSYARAADGTSKHSQTWKADPTVPQQPGLMKFVADVSKE |
Length | 640 |
Position | Head |
Organism | Aspergillus ruber CBS 135680 |
Kingdom | Fungi |
Lineage | Eukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes>
Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
|
Aromaticity | 0.06 |
Grand average of hydropathy | -0.497 |
Instability index | 51.64 |
Isoelectric point | 5.94 |
Molecular weight | 71730.24 |
Publications | PubMed=24811710
|
Function
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364140
|
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro
|
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro
|
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro
|
Interaction
Repeat regions
Repeats |
>MDP00097
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 95.47| 32| 38| 423| 459| 1
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423- 459 (45.49/39.02) H.VEWLESFIKdmyGVLksAGVDSDYSANLFSSVNPQR
462- 494 (49.99/28.23) HsLPKVEALVQ...GFL..VPLESTISGSLITPKSPFR
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No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level
2| 119.64| 39| 46| 268| 311| 2
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268- 311 (54.94/50.54) RVKINDRVTGCSKSTRSTADGEESIetrILQARDTvyEEELFHE
317- 355 (64.70/43.17) RIMGGQGVTTRQNLIRFAVSEEQEI...MLDLADT..DLESFSE
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