<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00092

Description Mediator of RNA polymerase II transcription subunit 16
SequenceMMDHDINVDDLFGEPGSLELGLSPTAPKGLAQRLDEMRLLGCCQKISWSRLGCIAYISRDGLAVNVRYLHCQPSDGRWRLSEDTPLFPVTEAHGNHPLVHICWNESGLELAVVDSSGRVSIYSISIALNSIAGQRQAAFDPDDEINQVVGMMWLNTQRSVHAFLQAAKVNGRWAYAPFRRRPIGPFHPANKAALICVTRSGLIKLLYQNPDSRWAEISAELKNTSYSDRLLTHASLVATQAGIIVVTHSVCQKICVYRVHVSWNPPQWDPSSPKQSNLFPVPSFRFAHGNVETPSGFWNAYRSTGENEEAPLSTNSIYALTHLEIIPGAADNPTGSTANPWILAVYSNPVPATPDHTEQNGSASIIVRWQLEAASQNLHPKFDEVASKKNHNAQAKPKMELRRLEDIHFDKYVISVDQAEHGTVLAITYDDSSITFYDPKTMAIFNGTDDNSTVTCLTQAGFHSPPEVSGLQISFSPSACGAVMLDSEGQMQLRLMEHSYGAENGLFDESKFSAAIAALTLAFCRGCGSDINTDDILMLVMRQLSSEAQTAFLNEIYRALPINCNFTVDQDKLMNHPYIPRCLSLQAALGFRDRYKPRIFTSAVPWAILHLRHGAVLFAYFFQYIKGTQTDPHDSDVLRMVLGNTRWVLDFSQYILNEVFDLADEFESVLSDQEAFTQKLKTTTSLPLIILLSSMSRTFLRFICRGLRGVHSGYNPSAANLAGDSRIYYSETCHLLDTSPVRIDVYEKFLAGVDSAVRHAYHGAGFGDTERPGPEKELLVNARIPPVLVNAVSAIFRSVVPAVRGEVDRLAVYLGDYTWLGVGDDKRTEVYRRTRDVDILKKIPLRVIVPDAGSRTNTTTPTNDDNKAGAEQRIRRCIRCCEVSSDTHPPRSLPAFQMIARLGLLRSCICGGMWALESRLPGGQLDGSMGSSTSPPAPGLQTESRTPGLMQGS
Length953
PositionTail
OrganismAspergillus ruber CBS 135680
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.08
Grand average of hydropathy-0.195
Instability index39.68
Isoelectric point6.17
Molecular weight105351.32
Publications
PubMed=24811710

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
GO - Biological Process








Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00092
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.31|      20|      43|     885|     906|       1
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  885-  906 (33.22/25.26)	SDTHPPrsLPAFQMIARL.GLLR
  931-  951 (33.09/18.59)	SSTSPP..APGLQTESRTpGLMQ
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     218.45|      52|     206|      43|      98|       2
---------------------------------------------------------------------------
   43-   97 (89.27/59.52)	CQKISWSRLgcIAYISRDGLaVNVRYLHCQPSDGRWRLS..EDTPL..FPVTE...AHGNHP
  163-  191 (27.27/ 9.56)	.........................FLQAAKVNGRWAYA.....PFrrRPIGP...FHPANK
  194-  230 (49.79/24.76)	...........LICVTRSGL.IKLLY...QNPDSRW..A..EISAE..LKNT....SYSDRL
  251-  290 (52.12/20.56)	CQKICVYRV..................HVSWNPPQWDPSspKQSNL..FPVPSfrfAHGN..
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     117.41|      36|      43|     723|     758|       3
---------------------------------------------------------------------------
  723-  758 (62.00/46.66)	GDSRIYYSETCHLLDT..SPVRIDVYEKFLAGVDSAVR
  767-  804 (55.41/40.80)	GDTERPGPEKELLVNAriPPVLVNAVSAIFRSVVPAVR
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---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.85|      18|     211|     408|     425|       5
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  408-  425 (31.92/23.51)	HFDKYVISVDQAEHGT.VL
  620-  638 (28.93/20.57)	YFFQYIKGTQTDPHDSdVL
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      98.75|      31|      40|     518|     552|       7
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  518-  552 (46.91/36.04)	ALTLafcrGCGSDINTDDIL..MLVMRQLSSEAQTAF
  559-  591 (51.84/29.39)	ALPI....NCNFTVDQDKLMnhPYIPRCLSLQAALGF
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00092 with Med16 domain of Kingdom Fungi
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