<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00091

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGNITNVHVIDGFSSIHWRIYTEEPGITNHPSETPTNGHTILKHLSRLKDFELRLRNLGCLVSCYPRRLGLWVFSSNSNFDSLAPLNQGNDGLNRLQVGSLTLKVSASGSVSSRELVRTLSTEPQAPNVNTAGSQRSQNVPNPPRRIEGYGTSAAIYASFISAVTGAISLQLIRRHGAIPLGSRTLFTAVEKDGYETRIANDSYTATPSLSILHIQLTSGGKLTVALQTIAQHGISRLQSPKNGLDKLRDTQPGLDIWLSPNATVARLVSFNTSSQDSISPNPSGGNDASGLAAVKRSQWKQCVLEWLGNFGLLFDSHEEEQWIEVEVWEPFYSRLAGEIFRQSEEGPTAFPLKRILWPARYCFRRTKSIALDASYGKQDSCHLMDSPLGLADEWHVTGNFVHDEATSIAPSGGFQDQPMRDSEISPSKAEFPEPLESLSRIAQYPDLQATNLVYPTPPDGATALSSDMFADQPDLPLPQTQHRGQPKLKQASFKEQADSGITMDIGPSAGLTVGSGLYDMNGDDDLFGEINDRDFGTRGITDADFSFFDDPDFGDMGEAPAADNTQSTPNIAEANLKEDDEQPSPDFPLPDSHVVTTAEGMNAPQTDVAEQEAVIPSKRETSEIRMSSPREESSQPISPPLSPVEVKKILFSESDDGDQSTVKRKRKQSHFTPVSFKQKIGDWNQKYGAEGRFWFSGPGVSTVMESVNPPNDIPTIGLPRRSGKAAVKFDNPAVTDEQDVLSGDAKGSSHSTSDSSSVSSDDDDSDEVMSEREPSPVNLTRKRKRAQSNTSGSITQVLSNPLVENAQLVSASKAENSTFLGNLLSTFSDWSLLGYFSVSQNQQPPTISQKDEQIQVAQLLVDQITQSSLDHVIDGQIGLSGLDNEMYTLRNIFEDTVFTDEVGRLDLKSYALLQNDSSPPSSEGLTPHQLPQRKEAAKGTISKLVPPHLRIRRGKGYLEALPPAISFWETFDLEPAHGPKDISAYCIHPRVMTDAADAFLERLGLLYSACNLGNHARGDMCFERGLGSWNTEVSSYLSTVQSLRGLCEELGNALSGSQPRTENFVVYVINPFTHAAALADICAAFWQLFQKYIMGTDNQQAGKFNELVLQIIPISFVMSPESIVVPSQSDYLSLALEVYSRCPSKDSESNLVHCAPPVLLTESAPKAISFKLVPERLSPLQDGRSLHIACSRSLDQRWITVAWSDNTGAIQRMMSYCLRYRNSGAVRGISDVRNEIWGTTQTIMDRIQARWRIIIVNTEPVDQDELDTWTNLAEQHNKSKPIPLDLMILHVNATTDFSLEPPSLLIPTSVFNAQASSTPVATPGPSAASPDQYGSAPTPTNGGSAPMSATTPDFQPESESDFFLADIRDESWNVILSHRLNSSPYLTEYRPALASGYLLRRKGPTDGDGVFATNVNLIHSRHPTSSHETLLKEILGMYHDLAILARARGTRCVQRNTLPWHIATAVRAQELLSYVF
Length1481
PositionKinase
OrganismAspergillus ruber CBS 135680
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.405
Instability index51.89
Isoelectric point5.12
Molecular weight162412.41
Publications
PubMed=24811710

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
ECO:0000256	RuleBase:RU364134
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00091
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.15|      36|      50|     463|     498|       1
---------------------------------------------------------------------------
  408-  449 (30.99/10.49)	.D.EATS.IApS..GGFQDQPmrDSEIsPS....KAEF..PEPLEslsRIAQY
  463-  498 (66.71/30.19)	PD.GATA.LS.S..DMFADQP..DLPL.PQ....TQHR..GQPKL...KQASF
  512-  550 (39.61/15.24)	PSaGLTV.GS.GlyDMNGDD...DL.F.GE....INDRdfGTRGI...TDADF
  574-  605 (26.83/ 8.20)	PN.IAEAnLK.E..DDEQPSP..DFPL.PDshvvTTAE..G............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.42|      42|     435|     920|    1034|       2
---------------------------------------------------------------------------
  992- 1034 (74.85/136.47)	IHPRVMTDAADAFL.ERLGLLYSACNLGnHARGDMCFERGLGSW
 1423- 1465 (73.57/16.48)	IHSRHPTSSHETLLkEILGMYHDLAILA.RARGTRCVQRNTLPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.16|      19|      23|     874|     894|       3
---------------------------------------------------------------------------
  874-  894 (29.78/28.06)	L..DHVIDGQIGlsGLDNEMYTL
  897-  917 (27.37/18.07)	IfeDTVFTDEVG..RLDLKSYAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.14|      28|     435|     195|     359|       4
---------------------------------------------------------------------------
  160-  188 (42.51/138.65)	IYASFISAVTGAISLQLIRRHGAIPLgSR
  332-  359 (51.63/30.02)	VWEPFYSRLAGEIFRQSEEGPTAFPL.KR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.11|      64|     621|     701|     779|       7
---------------------------------------------------------------------------
   79-  117 (38.32/11.77)	SSNSNFDSLAPLNQgNDGLNRLQVGSlTLKVSASGSVSS...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  701-  728 (26.89/ 9.04)	.......................................relvrtlstepqapnvntagsqrsqnvpnpprriegygtsaaiyasfisavtgaislqlirrhgaiplgsrtlftavekdgyetriandsytatpslsilhiqltsggkltvalqtiaqhgisrlqspkngldklrdtqpgldiwlspnatvarlvsfntssqdsispnpsggndasglaavkrsqwkqcvlewlgnfgllfdsheeeqwievevwepfysrlageifrqseegptafplkrilwparycfrrtksialdasygkqdschlmdsplgladewhvtgnfvhdeatsiapsggfqdqpmrdseispskaefpepleslsriaqypdlqatnlvyptppdgatalssdmfadqpdlplpqtqhrgqpklkqasfkeqadsgitmdigpsagltvgsglydmngdddlfgeindrdfgtrgitdadfsffddpdfgdmgeapaadntqstpniaeanlkeddeqpspdfplpdshvvttaegmnapqtdvaeqeavipskretseirmsspreessqpispplspvevkkilfsesddgdqstvkrkrkqshftpvsfkqkigdwnqkygaegrfwfSGPgVSTVMESVNPPNDIPTIGLPRRSG
  729-  765 (46.97/36.95)	KAAVKFDNPAVTDE.QDVLSGDAKGS.SHSTSDSSSVSS...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1322- 1348 (30.93/ 7.44)	..................................................................ddddsdevmserepspvnltrkrkraqsntsgsitqvlsnplvenaqlvsaskaenstflgnllstfsdwsllgyfsvsqnqqpptisqkdeqiqvaqllvdqitqssldhvidgqiglsgldnemytlrnifedtvftdevgrldlksyallqndssppssegltphqlpqrkeaakgtisklvpphlrirrgkgylealppaisfwetfdlepahgpkdisaycihprvmtdaadaflerlgllysacnlgnhargdmcferglgswntevssylstvqslrglceelgnalsgsqprtenfvvyvinpfthaaaladicaafwqlfqkyimgtdnqqagkfnelvlqiipisfvmspesivvpsqsdylslalevysrcpskdsesnlvhcappvlltesapkaisfklvperlsplqdgrslhiacsrsldqrwitvawsdntgaiqrmmsyclryrnsgavrgisdvrneiwgttqtimdriqarwriiivntepvdqdeldtwtnlaeqhnkskpipldlmilhvnattdfsleppslliptsvfnaqasSTP.VATPGPSAASPDQYGSAPTPTNGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.69|      13|      16|     930|     944|       8
---------------------------------------------------------------------------
  930-  944 (19.85/17.59)	LTPHQLPQRKeaAKG
  949-  961 (24.84/14.86)	LVPPHLRIRR..GKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.19|      17|     437|     379|     405|      10
---------------------------------------------------------------------------
    1-   17 (33.38/14.56)	MDFPGGNITNVHVIDGF
  389-  405 (33.80/14.94)	MDSPLGLADEWHVTGNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.30|      24|     437|     632|     681|      11
---------------------------------------------------------------------------
  639-  650 ( 4.46/ 6.63)	................SQPISPPLspVE
  666-  680 (13.90/22.17)	TVKRKRKQSHfTPVS.............
  785-  809 (38.94/ 8.97)	TRKRKRAQSN.TSGSiTQVLSNPL..VE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00091 with Med13 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) ASSTPVATPGPSAASPDQYGSAPTPTNGGSAPMSATTPDFQ
2) GATALSSDMFADQPDLPLPQTQHRGQPKLKQASFKEQADSGITMDIGPSAGLTVGSGLY
3) LVRTLSTEPQAPNVNTAGSQRSQNVPNPPRR
4) PGVSTVMESVNPPNDIPTIGLPRRSGKAAVKFDNPAVTDEQDVLSGDAKGSSHSTSDSSSVSSDDDDSDEVMSEREPSPVNLTRKRKRAQSNTSGSITQV
5) RGITDADFSFFDDPDFGDMGEAPAADNTQSTPNIAEANLKEDDEQPSPDFPLPDSHVVTTAEGMNAPQTDVAEQEAVIPSKRETSEIRMSSPREESSQPISPPLSPVEVKKILFSESDDGDQSTVKRKRKQSHF
1320
465
120
703
543
1360
523
150
802
676










Molecular Recognition Features






MoRF SequenceStartStop




1) INDRDFGTRGITDADF
2) KYGAEGRFW
3) PPLSPVEVKKILFSE
4) SHFTPVSFKQKIGDWN
5) VKRKRK
535
691
644
674
667
550
699
658
689
672