<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00091

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDFPGGNITNVHVIDGFSSIHWRIYTEEPGITNHPSETPTNGHTILKHLSRLKDFELRLRNLGCLVSCYPRRLGLWVFSSNSNFDSLAPLNQGNDGLNRLQVGSLTLKVSASGSVSSRELVRTLSTEPQAPNVNTAGSQRSQNVPNPPRRIEGYGTSAAIYASFISAVTGAISLQLIRRHGAIPLGSRTLFTAVEKDGYETRIANDSYTATPSLSILHIQLTSGGKLTVALQTIAQHGISRLQSPKNGLDKLRDTQPGLDIWLSPNATVARLVSFNTSSQDSISPNPSGGNDASGLAAVKRSQWKQCVLEWLGNFGLLFDSHEEEQWIEVEVWEPFYSRLAGEIFRQSEEGPTAFPLKRILWPARYCFRRTKSIALDASYGKQDSCHLMDSPLGLADEWHVTGNFVHDEATSIAPSGGFQDQPMRDSEISPSKAEFPEPLESLSRIAQYPDLQATNLVYPTPPDGATALSSDMFADQPDLPLPQTQHRGQPKLKQASFKEQADSGITMDIGPSAGLTVGSGLYDMNGDDDLFGEINDRDFGTRGITDADFSFFDDPDFGDMGEAPAADNTQSTPNIAEANLKEDDEQPSPDFPLPDSHVVTTAEGMNAPQTDVAEQEAVIPSKRETSEIRMSSPREESSQPISPPLSPVEVKKILFSESDDGDQSTVKRKRKQSHFTPVSFKQKIGDWNQKYGAEGRFWFSGPGVSTVMESVNPPNDIPTIGLPRRSGKAAVKFDNPAVTDEQDVLSGDAKGSSHSTSDSSSVSSDDDDSDEVMSEREPSPVNLTRKRKRAQSNTSGSITQVLSNPLVENAQLVSASKAENSTFLGNLLSTFSDWSLLGYFSVSQNQQPPTISQKDEQIQVAQLLVDQITQSSLDHVIDGQIGLSGLDNEMYTLRNIFEDTVFTDEVGRLDLKSYALLQNDSSPPSSEGLTPHQLPQRKEAAKGTISKLVPPHLRIRRGKGYLEALPPAISFWETFDLEPAHGPKDISAYCIHPRVMTDAADAFLERLGLLYSACNLGNHARGDMCFERGLGSWNTEVSSYLSTVQSLRGLCEELGNALSGSQPRTENFVVYVINPFTHAAALADICAAFWQLFQKYIMGTDNQQAGKFNELVLQIIPISFVMSPESIVVPSQSDYLSLALEVYSRCPSKDSESNLVHCAPPVLLTESAPKAISFKLVPERLSPLQDGRSLHIACSRSLDQRWITVAWSDNTGAIQRMMSYCLRYRNSGAVRGISDVRNEIWGTTQTIMDRIQARWRIIIVNTEPVDQDELDTWTNLAEQHNKSKPIPLDLMILHVNATTDFSLEPPSLLIPTSVFNAQASSTPVATPGPSAASPDQYGSAPTPTNGGSAPMSATTPDFQPESESDFFLADIRDESWNVILSHRLNSSPYLTEYRPALASGYLLRRKGPTDGDGVFATNVNLIHSRHPTSSHETLLKEILGMYHDLAILARARGTRCVQRNTLPWHIATAVRAQELLSYVF
Length1481
PositionKinase
OrganismAspergillus ruber CBS 135680
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Eurotiomycetes> Eurotiomycetidae> Eurotiales> Aspergillaceae> Aspergillus.
Aromaticity0.07
Grand average of hydropathy-0.405
Instability index51.89
Isoelectric point5.12
Molecular weight162412.41
Publications
PubMed=24811710

Function

Annotated function Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00091
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.15|      36|      50|     463|     498|       1
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  408-  449 (30.99/10.49)	.D.EATS.IApS..GGFQDQPmrDSEIsPS....KAEF..PEPLEslsRIAQY
  463-  498 (66.71/30.19)	PD.GATA.LS.S..DMFADQP..DLPL.PQ....TQHR..GQPKL...KQASF
  512-  550 (39.61/15.24)	PSaGLTV.GS.GlyDMNGDD...DL.F.GE....INDRdfGTRGI...TDADF
  574-  605 (26.83/ 8.20)	PN.IAEAnLK.E..DDEQPSP..DFPL.PDshvvTTAE..G............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     148.42|      42|     435|     920|    1034|       2
---------------------------------------------------------------------------
  992- 1034 (74.85/136.47)	IHPRVMTDAADAFL.ERLGLLYSACNLGnHARGDMCFERGLGSW
 1423- 1465 (73.57/16.48)	IHSRHPTSSHETLLkEILGMYHDLAILA.RARGTRCVQRNTLPW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.16|      19|      23|     874|     894|       3
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  874-  894 (29.78/28.06)	L..DHVIDGQIGlsGLDNEMYTL
  897-  917 (27.37/18.07)	IfeDTVFTDEVG..RLDLKSYAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      94.14|      28|     435|     195|     359|       4
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  160-  188 (42.51/138.65)	IYASFISAVTGAISLQLIRRHGAIPLgSR
  332-  359 (51.63/30.02)	VWEPFYSRLAGEIFRQSEEGPTAFPL.KR
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.11|      64|     621|     701|     779|       7
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   79-  117 (38.32/11.77)	SSNSNFDSLAPLNQgNDGLNRLQVGSlTLKVSASGSVSS...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
  701-  728 (26.89/ 9.04)	.......................................relvrtlstepqapnvntagsqrsqnvpnpprriegygtsaaiyasfisavtgaislqlirrhgaiplgsrtlftavekdgyetriandsytatpslsilhiqltsggkltvalqtiaqhgisrlqspkngldklrdtqpgldiwlspnatvarlvsfntssqdsispnpsggndasglaavkrsqwkqcvlewlgnfgllfdsheeeqwievevwepfysrlageifrqseegptafplkrilwparycfrrtksialdasygkqdschlmdsplgladewhvtgnfvhdeatsiapsggfqdqpmrdseispskaefpepleslsriaqypdlqatnlvyptppdgatalssdmfadqpdlplpqtqhrgqpklkqasfkeqadsgitmdigpsagltvgsglydmngdddlfgeindrdfgtrgitdadfsffddpdfgdmgeapaadntqstpniaeanlkeddeqpspdfplpdshvvttaegmnapqtdvaeqeavipskretseirmsspreessqpispplspvevkkilfsesddgdqstvkrkrkqshftpvsfkqkigdwnqkygaegrfwfSGPgVSTVMESVNPPNDIPTIGLPRRSG
  729-  765 (46.97/36.95)	KAAVKFDNPAVTDE.QDVLSGDAKGS.SHSTSDSSSVSS...................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................................
 1322- 1348 (30.93/ 7.44)	..................................................................ddddsdevmserepspvnltrkrkraqsntsgsitqvlsnplvenaqlvsaskaenstflgnllstfsdwsllgyfsvsqnqqpptisqkdeqiqvaqllvdqitqssldhvidgqiglsgldnemytlrnifedtvftdevgrldlksyallqndssppssegltphqlpqrkeaakgtisklvpphlrirrgkgylealppaisfwetfdlepahgpkdisaycihprvmtdaadaflerlgllysacnlgnhargdmcferglgswntevssylstvqslrglceelgnalsgsqprtenfvvyvinpfthaaaladicaafwqlfqkyimgtdnqqagkfnelvlqiipisfvmspesivvpsqsdylslalevysrcpskdsesnlvhcappvlltesapkaisfklvperlsplqdgrslhiacsrsldqrwitvawsdntgaiqrmmsyclryrnsgavrgisdvrneiwgttqtimdriqarwriiivntepvdqdeldtwtnlaeqhnkskpipldlmilhvnattdfsleppslliptsvfnaqasSTP.VATPGPSAASPDQYGSAPTPTNGG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.69|      13|      16|     930|     944|       8
---------------------------------------------------------------------------
  930-  944 (19.85/17.59)	LTPHQLPQRKeaAKG
  949-  961 (24.84/14.86)	LVPPHLRIRR..GKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      67.19|      17|     437|     379|     405|      10
---------------------------------------------------------------------------
    1-   17 (33.38/14.56)	MDFPGGNITNVHVIDGF
  389-  405 (33.80/14.94)	MDSPLGLADEWHVTGNF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      57.30|      24|     437|     632|     681|      11
---------------------------------------------------------------------------
  639-  650 ( 4.46/ 6.63)	................SQPISPPLspVE
  666-  680 (13.90/22.17)	TVKRKRKQSHfTPVS.............
  785-  809 (38.94/ 8.97)	TRKRKRAQSN.TSGSiTQVLSNPL..VE
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00091 with Med13 domain of Kingdom Fungi
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