<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00090

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMADDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEEYVFQKCLSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQKLRMLRPYCENLKLRAQQCRMEGNMEAAQKLETMLGVLEGRRVVSLEYLLNLENWIHKKADFLAATTHNPHAAAMQNGHMGMAGQGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPESHHDPHCALVKCKIKGQQVPALRLVIPLSYPASSVTVDRAAIDLDAFFYDDLQNVVHERLARPGLHSITEFLNTWETTVRQYTSNQNNANTTISPFDELFQNYDNIIT
Length744
PositionTail
OrganismAncylostoma ceylanicum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma.
Aromaticity0.06
Grand average of hydropathy-0.842
Instability index65.34
Isoelectric point6.28
Molecular weight82074.09
Publications
PubMed=25730766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00090
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     478.74|      65|      65|     158|     222|       1
---------------------------------------------------------------------------
   82-  152 (69.50/13.62)	........PSFHSP.P..CSA...PnvnntnntnsttsyrtsvP..P.DPQ..P...T.QTRNQSQPT..P.....SS.....................TTQ.......QVPIQQQ..........PPA.............PN.Q...PGfPSPD
  153-  221 (132.87/32.72)	QsrgpP..PTYGAP.P..LGQ...P..................P..P.QMQ..P...TGQPVPQQQMM..P.....QGGCP.............PYQMMSPQ.......QSQQQQQ........LLPPY.............DA.R...MQ.KQPK
  222-  286 (81.36/17.19)	Q...ePlsRSWDAQ.G..MHY...P..................P..P.QQQwaPhpgYGQP.PQQQQM............P.............PHH...SQ.......QSQQGQQ..........PPV.............SG.QstvLE.ALIN
  287-  364 (76.95/15.86)	Q.......PQYPST.PhqMGR......................H..P.QMM..M...SGPNAP....M..G.....AGG.................HMGGPM.......DSQHDQQqiynqklrMLRPYcenlklraqqcrmEG.N...ME.AAQK
  445-  537 (65.53/12.42)	........TGYVPP.P..MHQgsyP..................PmhPqQMW..P...PPQHLQQQSMMmgPpmsqsQGGGPmqsyrespvehhrPYPSMRPQmrpppvvQSVQPQ............PV.............DPlR...MG.SGAS
  538-  586 (52.52/ 8.50)	M...eP..ILNAAPaP..VIP...P..................R..P.TTS..A...TT.PV.....M..T.....GSGNG.............GNGSAGSA.......GSAEQ............PGV.............D.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.65|      17|      31|      63|      79|       2
---------------------------------------------------------------------------
   63-   79 (28.42/18.93)	VINAINCNSKSAAVPSV
   94-  110 (28.24/18.77)	VNNTNNTNSTTSYRTSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00090 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQ
2) MADDDWPSQRFRDHVINRLEPELARNRQNAPNLPVPGDARQVEE
3) QGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPES
74
1
419
334
44
637










Molecular Recognition Features






MoRF SequenceStartStop




NANANA