<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00089

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMIGHLRDSVITSSIDCRAGKHGKSITFLTPDDSAVFYDLKQCLMESPISTCPIELANHPDAQQKPGTFTTKKRQDETLFKEPELARNRQNAPNLPVPGDARQVEEYVFQKCLSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQKLRMLRPYCENLKLRAQQCRMEGNMEAAQKLETMLGVLEGRRVVSLEYLLNLENWIHKKADFLAATTHNPHAAAMQNGHMGMAGQGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPESHHDPHCALVKCKIKGQQVPALRLVIPLSYPASSVTVDRAAIDLDAFFYDDLQNVVHERLARPGLHSITEFLNTWETTVRQYTSNQNNANTTISPFDELFQNYDNIIT
Length805
PositionTail
OrganismAncylostoma ceylanicum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma.
Aromaticity0.06
Grand average of hydropathy-0.797
Instability index64.66
Isoelectric point6.40
Molecular weight88613.58
Publications
PubMed=25730766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00089
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             8|     582.92|      65|      65|     219|     283|       1
---------------------------------------------------------------------------
  143-  213 (66.74/15.44)	........PSFHSP.P..C..SAPnvnntnntnsttsyrtsvPPDPQ..P...T.QTRNQSQPTPSSTT...Q.....QVPIQQQ...........PPA.............PN.Q...PGfPSPD
  214-  282 (129.15/37.36)	QsrgpP..PTYGAP.P..L..GQP..................PPQMQ..P...TGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQ........LL.PPY.............DA.R...MQ.KQPK
  283-  347 (79.39/19.89)	Q...ePlsRSWDAQ.G..M..HYP..................PPQQQwaPhpgYGQP.PQQQQM.....PPHH...SQQSQQGQQ...........PPV.............SG.QstvLE.ALIN
  348-  425 (74.80/18.28)	Q.......PQYPST.PhqM..GR...................HPQMM..M...SGPNAP....MGAGG....HMGGPMDSQHDQQqiynqklrML.RPYcenlklraqqcrmEG.N...ME.AAQK
  453-  500 (47.31/ 8.62)	K....K..ADFLAA.T..T..HNP..................HAAAM..Q...NGHMGMAGQGMVDGINAVLNASSDHHPNS............................................
  502-  549 (78.04/19.41)	..........YGAQ.T.....GYV..................PPPMH..Q...GSYP.P...MHPQQMWPP.....PQHLQQQSM........MMgPP.....................MS.QSQG
  550-  598 (58.24/12.46)	G..gpM..QSYRES.P..VehHRP..................YPSMR..P...QMRP............PP..VV...QSVQPQ.............PV.............DPlR...MG.SGAS
  599-  647 (49.24/ 9.30)	M...eP..ILNAAPaP..V..IPP..................RPTTS..A...TT.PV.....MTGSGNGGNGSAGSAGSAEQ.............PGV.............D.............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.65|      17|      28|     124|     140|       3
---------------------------------------------------------------------------
  124-  140 (28.42/17.46)	VINAINCNSKSAAVPSV
  155-  171 (28.24/17.31)	VNNTNNTNSTTSYRTSV
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00089 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQ
2) PDAQQKPGTFTTKKRQDETLFKEPELARNRQNAPNLPVPGDA
3) QGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPES
135
59
480
395
100
698










Molecular Recognition Features






MoRF SequenceStartStop




NANANA