<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00088

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMLMLSIIFNTSHAYLVCTRIDKEPELARNRQNAPNLPVPGDARQVEEYVFQKCLSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQKLRMLRPYCENLKLRAQQCRMEGNMEAAQKLETMLGVLEGRRVVSLEYLLNLENWIHKKADFLAATTHNPHAAAMQNGHMGMAGQGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPESHHDPHCALVKCKIKGQQVPALRLVIPLSYPASSVTVDRAAIDLDAFFYDDLQNVVHERLARPGLHSITEFLNTWETTVRQYTSNQNNANTTISPFDELFQNYDNIIT
Length747
PositionTail
OrganismAncylostoma ceylanicum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma.
Aromaticity0.06
Grand average of hydropathy-0.787
Instability index64.76
Isoelectric point6.43
Molecular weight82272.60
Publications
PubMed=25730766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00088
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             7|     582.03|      65|      65|     161|     225|       1
---------------------------------------------------------------------------
   85-  156 (72.13/15.40)	...PSFHSP.P..C..SAPnvnntnntnsttsyrtsvPPDPQ..P...T.QTRNQSQPTPSSTT...Q.....QVPIQQQ...........PPAPN.Q...PGfPSPDQ
  161-  225 (137.14/36.15)	P..PTYGAP.P..L..GQP..................PPQMQ..P...TGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQ........LL.PPYDA.R...MQ.KQPKQ
  227-  290 (85.05/19.53)	PlsRSWDAQ.G..M..HYP..................PPQQQwaPhpgYGQP.PQQQQM.....PPHH...SQQSQQGQQ...........PPVSG.QstvLE.ALINQ
  291-  355 (78.41/17.41)	...PQYPST.PhqM..GR...................HPQMM..M...SGPNAP....MGAGG....HMGGPMDSQHDQQqiynqklrML.RPYCE.N...LK.LRAQQ
  441-  492 (88.38/20.59)	N..SMYGAQ.T.....GYV..................PPPMH..Q...GSYP.P...MHPQQMWPP.....PQHLQQQSM........MMgPP........MS.QSQGG
  495-  541 (65.88/13.41)	M..QSYRES.P..VehHRP..................YPSMR..P...QMRP............PP..VV...QSVQPQ.............PVDPlR...MG.SGASM
  543-  589 (55.05/ 9.96)	P..ILNAAPaP..V..IPP..................RPTTS..A...TT.PV.....MTGSGNGGNGSAGSAGSAEQ.............PGVD..............
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.65|      17|      28|      66|      82|       2
---------------------------------------------------------------------------
   66-   82 (28.42/18.05)	VINAINCNSKSAAVPSV
   97-  113 (28.24/17.89)	VNNTNNTNSTTSYRTSV
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00088 with Med15 domain of Kingdom Metazoa
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