<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00087

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMTWVLLVDIKLPLSSRSHSHAVGVFVTPLGRAGKHGKSITFLTPDDSAVFYDLKQCLMESPISTCPIELANHPDAQQKPGTFTTKKRQDETLFKEPELARNRQNAPNLPVPGDARQVEEYVFQKCLSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQKLRMLRPYCENLKLRAQQCRMEGNMEAAQKLETMLGVLEGRRVVSLEYLLNLENWIHKKADFLAATTHNPHAAAMQNGHMGMAGQGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPESHHDPHCALVKCKIKGQQVPALRLVIPLSYPASSVTVDRAAIDLDAFFYDDLQNVVHERLARPGLHSITEFLNTWETTVRQYTSNQNNANTTISPFDELFQNYDNIIT
Length819
PositionTail
OrganismAncylostoma ceylanicum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma.
Aromaticity0.06
Grand average of hydropathy-0.765
Instability index63.34
Isoelectric point6.56
Molecular weight90127.42
Publications
PubMed=25730766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00087
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             9|     609.47|      65|      65|     233|     297|       1
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   61-  128 (43.69/ 7.47)	..........P..I..ST.............CPIELanH..P...DAQQKP.GTFTTKKRQDETLFKEPELARNRQN........ApnL.PvPG.............DA.RqveeyvFQ.KCLS...........................K
  162-  228 (70.73/16.99)	P..PC.SAP.N..V..NNtnntnsttsyrtsVPPDP..Q..P...T.QTRNQSQPTPSSTT...Q.....QVPIQQQ.............P.PA.............PN.Q......PGfPSPD...........................Q
  233-  297 (133.25/39.01)	P..PTYGAP.P..L..GQ.............PPPQM..Q..P...TGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQ........L..L.P.PY.............DA.R......MQ.KQPK...........................Q
  299-  362 (80.50/20.43)	PlsRSWDAQ.G..M..HY.............PPPQQ..QwaPhpgYGQP.PQQQQM.....PPHH...SQQSQQGQQ.............P.PV.............SG.Q...stvLE.ALIN...........................Q
  363-  467 (50.41/ 9.83)	...PQYPST.PhqM..GR..............HPQM..M..M...SGPNAP....MGAGG....HMGGPMDSQHDQQqiynqklrM..L.R.PYcenlklraqqcrmEG.N......ME.AAQKletmlgvlegrrvvsleyllnlenwihK
  468-  514 (42.60/ 7.09)	K..ADFLAA.T..T..HN.............PHAAA..M..Q...NGHMGMAGQGMVDGINAVLNASSDHHPNS..............................................................................
  516-  564 (77.61/19.42)	.....YGAQ.T.....GY.............VPPPM..H..Q...GSYP.P...MHPQQMWPP.....PQHLQQQSM........M..MgP.P........................MS.QSQG...........................G
  567-  613 (61.11/13.60)	M..QSYRES.P..VehHR.............PYPSM..R..P...QMRP............PP..VV...QSVQPQ................PV.............DPlR......MG.SGAS...........................M
  615-  661 (49.58/ 9.54)	P..ILNAAPaP..V..IP.............PRPTT..S..A...TT.PV.....MTGSGNGGNGSAGSAGSAEQ...............P.GV.............D............................................
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00087 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQ
2) PDAQQKPGTFTTKKRQDETLFKEPELARNRQNAPNLPVPGDA
3) QGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPES
149
73
494
409
114
712










Molecular Recognition Features






MoRF SequenceStartStop




NANANA