<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00086

Description Mediator of RNA polymerase II transcription subunit 15
SequenceMLMLSIIFNTSHAYLVCTRIDKEPELARNRQNAPNLPVPGDARQVEEEPELARNRQNAPNLPVPGDARQVEEYVFQKCLSKDEYMRTIAKVINAINCNSKSAAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQKLRMLRPYCENLKLRAQQCRMEGNMEAAQKLETMLGVLEGRRVVSLEYLLNLENWIHKKADFLAATTHNPHAAAMQNGHMGMAGQGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPESHHDPHCALVKCKIKGQQVPALRLVIPLSYPASSVTVDRAAIDLDAFFYDDLQNVVHERLARPGLHSITEFLNTWETTVRQYTSNQNNANTTISPFDELFQNYDNIIT
Length772
PositionTail
OrganismAncylostoma ceylanicum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma.
Aromaticity0.05
Grand average of hydropathy-0.805
Instability index65.86
Isoelectric point6.29
Molecular weight85054.59
Publications
PubMed=25730766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
ECO:0000256	RuleBase:RU364148
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro
GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro
GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro

Interaction

Binary Interactions











Repeat regions





Repeats

>MDP00086
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     143.63|      22|      22|      23|      44|       1
---------------------------------------------------------------------------
   23-   44 (39.23/10.47)	EPELARNRQNAPNLPVPGDARQ
   48-   69 (39.23/10.47)	EPELARNRQNAPNLPVPGDARQ
  167-  184 (31.79/ 6.97)	QPP.APNQ...PGFPSPDQSRG
  477-  494 (33.38/ 7.72)	PPPM....HQGSYPPMHPQQMW
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             4|     164.25|      33|      34|     238|     270|       2
---------------------------------------------------------------------------
  188-  215 (38.70/ 9.42)	TYGAPPLGQPP........PQMQ.............PTG....QPVPQ......QQmmP...
  216-  255 (36.19/ 8.20)	....QG.GCPPyqmmspqqSQQQ.........qqllPPYDARMQKQPK......QE..PLSR
  256-  290 (55.76/17.75)	SWDAQGMHYPP........PQQQ.........waphPGYGQPPQQQ........QM..PPHH
  291-  341 (33.60/ 6.93)	SQQSQQGQQPP........VSGQstvlealinqpqyPSTPHQMGRHPQmmmsgpNA..PMG.
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     107.58|      30|      34|     495|     524|       3
---------------------------------------------------------------------------
  495-  524 (60.96/20.15)	PPP..QHLQQQSM...MMGPPMSQSQGGGPMQSYR
  525-  559 (46.62/13.53)	ESPveHHRPYPSMrpqMRPPPVVQSVQPQPVDPLR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      87.73|      28|      30|      91|     120|       4
---------------------------------------------------------------------------
   91-  120 (46.86/27.87)	VINAINCNSKSA...AVPSVLQPS...FHSPPcsAP
  122-  155 (40.87/17.94)	VNNTNNTNSTTSyrtSVPPDPQPTqtrNQSQP..TP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     105.11|      32|      34|     589|     622|       5
---------------------------------------------------------------------------
  589-  621 (55.68/30.39)	PvMTGSGN.GGNGSAGS...AGSAEQPGVDDLYNMDD
  626-  661 (49.43/19.57)	P.MEAVGNvQGNGNKPSlpdAARREFSQLSDRFEFDN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.80|      27|      42|     386|     426|       6
---------------------------------------------------------------------------
  386-  413 (39.94/40.75)	NMEAAQKLETMLGvLEGRRVV.SLEYLLN
  431-  458 (44.86/17.37)	NPHAAAMQNGHMG.MAGQGMVdGINAVLN
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00086 with Med15 domain of Kingdom Metazoa


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) AAVPSVLQPSFHSPPCSAPNVNNTNNTNSTTSYRTSVPPDPQPTQTRNQSQPTPSSTTQQVPIQQQPPAPNQPGFPSPDQSRGPPPTYGAPPLGQPPPQMQPTGQPVPQQQMMPQGGCPPYQMMSPQQSQQQQQLLPPYDARMQKQPKQEPLSRSWDAQGMHYPPPQQQWAPHPGYGQPPQQQQMPPHHSQQSQQGQQPPVSGQSTVLEALINQPQYPSTPHQMGRHPQMMMSGPNAPMGAGGHMGGPMDSQHDQQQIYNQ
2) LARNRQNAPNLPVPGDARQVEEEPELARNRQNAPNLPVPGDA
3) QGMVDGINAVLNASSDHHPNSMYGAQTGYVPPPMHQGSYPPMHPQQMWPPPQHLQQQSMMMGPPMSQSQGGGPMQSYRESPVEHHRPYPSMRPQMRPPPVVQSVQPQPVDPLRMGSGASMEPILNAAPAPVIPPRPTTSATTPVMTGSGNGGNGSAGSAGSAEQPGVDDLYNMDDFLPTPMEAVGNVQGNGNKPSLPDAARREFSQLSDRFEFDNNPES
102
26
447
362
67
665










Molecular Recognition Features






MoRF SequenceStartStop




NANANA