<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00061

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMDDVDHSKPALPVVPDKCGPPTISLNYLLDFAIQQIYHEITVLSELLPKKLDGDRKISLVQFAHSTRMLFVKLLAVVKWVKSSKKFESCAAICYLLDQQSQYFIETADRLVTISREELVMARLPAFQVTAAVDVLTQGTYLHLPTIIQERFTLKPKIAPIDEANVLLRLNQVLQYRISKVASTLSPRIKGIVIKNGMLILTVPGEFEVNLTVLGEREQTPWTLLNIKMLVEDYEIGYGAQLVHPLQLHMLHTVLQSRMDVAKNPINEVYNFLHTFAQSLQLDVLFCQASQLAAGRLRNKIVIEKYDPKERVLSIGYWVQRITKKGIGAHIRLVPQYRVTIYGDEADDTTLKVRHYPIAPDLGQLDDRTGRLSIDRLLSETLVVRCRERLLRIRKRLKAAKPLSIVLYAGAAAPCLWLPLLRDSVDTREECVVISVNMFSGRVLCSLDAIEFLPGSASELKELEISLYDGQSIDLLRKRIDRLKILLMIERYRRSVATLQVRIINENQMAPFFKKVHSLPADRICLQFIKEEHFYLVVTFVSNENLTVKMSLYLLCTLDDKVQMMELNKEKQLISAPIDGVVDIEAKTFGLSENDDVWTQSVKHNRLEPSMVRQLTTAVAAVDDRISFMRVCEELDKKRIGYRSVEEEPHVGGLILHITDVSAVGDVRCAAFLRNMARCCLRLDSRARVIWPLECCMVNIPLVRDLSPYKKGRKTGVWVHEQTGISVGGPVDTIATSIIERLTRYSHIYETVNRFAKAYDVHYNKLCSVQAYTFHKLVIAYGRERDQQLIVSFRPRNTTNDRFNLNFGQTLPISIYDSAEVNLQETTRWNAHCMMATILKEKFNAKSDLTELVHYLVTTSEPLQSLSFFSRIRFQSCKVLAQLFSVDIPYPLILKFHLMPINEVTLRLTYGHIHLEFIMLSGDSVAIRDSSRDKPRCAGLHQFFHLLSNGTSKSCKESESRFARTSSPAQPASLPPNVVDASPAGLSLSASLSVPPTSDASAVSPATFGAAAELETSSAPVVIDHETLRRAFLFTKFPGSNLLHAPLDDYLNALCFIRKLTLAFEAHMRHQSAGRVPFNDMRSGLDYVRITVPVAVPPPAQRSDTSAPQTPQQIGGLVSFNFRLDPHTLCIKLNVEYGKNSPPPSDVAILERYFEQVVSRLNNELAVFSFINLCRMVVNGAISGIAQVMNAQMDPSPSTYWNVSIQLVCLTRDQTNTSVRRYQIGTVFDANNVNVLLLICFRPSRVTSPRSNEKHLLRIIYNMQTNAVKQHGTEDESMSSVLMACSQEAARTGECPLWPAIRQCLDKVSSANVAGMPASVGYMPGSVGGPVSVGPVGSVGIGHNPGSIANPGSNT
Length1354
PositionTail
OrganismAncylostoma ceylanicum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma.
Aromaticity0.07
Grand average of hydropathy-0.036
Instability index44.56
Isoelectric point8.72
Molecular weight151759.99
Publications
PubMed=25730766

Function

Annotated function Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. 
GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00061
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     592.97|     194|     342|       2|     212|       1
---------------------------------------------------------------------------
    2-  212 (294.68/262.87)	DDVDHSKPALPVVPDkcgpptisLNYLLD....FAIQQIYHEITVL...SELL..PKKLDGDRKISLVQFAHSTR.MLFVKLLAvvkwvKSSKKFESCAAICylLDQQSQYFIETAD..RLVTISREELVMARLPAFQvTAAVDVLTQG.TYLH.LPTIIQERF.....TLKPKIaPIDEA.NVLLRLNQVLQYRI..SKVASTLSPRIKG.IVIKNGMLILTVPGEFEVNLTV
  247-  316 (31.49/10.15)	........................................................................................................................................................LHmLHTVLQSRM.....DVAKN..PINEVyNFLHTFAQSLQLDVlfCQASQLAAGRLRNkIVIEK.....YDPKERVLSIGY
  346-  547 (266.80/194.91)	DDTTLKVRHYPIAPD........LGQLDDrtgrLSIDRLLSETLVVrcrERLLriRKRLKAAKPLSIVLYAGAAApCLWLPLLR.....DSVDTREECVVIS..VNMFSGRVLCSLDaiEFLPGSASELKELEISLYD.GQSIDLLRKRiDRLK.ILLMI.ERYrrsvaTLQVRI..INE........NQMAPF.F..KKVHSLPADRICL.QFIKEEHFYLVVTFVSNENLTV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     122.08|      43|     347|     952|     999|       2
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  677-  707 (45.56/19.52)	RCCLRLDSR.ARVIWPLECCMVNiPLVRDLSP................
  952-  998 (65.53/45.59)	KSCKESESRfARTSSPAQPASLP.PNVVDASPAGLSLSASLsvpPTSD
 1003- 1017 (10.99/ 8.01)	..............................SPATFGAAAEL...ETSS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.35|      18|      18|    1314|    1331|       3
---------------------------------------------------------------------------
 1314- 1331 (36.77/21.73)	GMPASV..GYMPGSVGGPVS
 1333- 1352 (31.57/17.67)	GPVGSVgiGHNPGSIANPGS
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     136.97|      43|     102|     788|     832|       4
---------------------------------------------------------------------------
  788-  832 (71.71/50.99)	LIVSFR..PRNTTNDRfnLNFGQT.LPISIYDSAEVNLQETTRWNAHC
  891-  936 (65.26/39.81)	LILKFHlmPINEVTLR..LTYGHIhLEFIMLSGDSVAIRDSSRDKPRC
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00061 with Med14 domain of Kingdom Metazoa
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