Description | Mediator of RNA polymerase II transcription subunit 19 |
Sequence | MGDGTWGSSLPAHSSPAISTLSLKTKISFKTGAATAVTVTPFYTLKPELPPKSPMLGSSDLLTAYDLGAVYSRYCGAKKMREDLNSFLPQIYGNFNFSQAQDISSLKMLVEKPPITGKEINTLSSTAMSGFRLTPGPVDERYRYLFEKKREGDGMPVIYDMERKDYTAFQRYKNSLDSLDGDEPERKKHKSEKKEKKKKKDKKKKDKKDEERKHRKTAEGGGPTPPVMMEF |
Length | 231 |
Position | Head |
Organism | Ancylostoma ceylanicum |
Kingdom | Metazoa |
Lineage | Eukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma. |
Aromaticity | 0.09 |
Grand average of hydropathy | -0.884 |
Instability index | 36.73 |
Isoelectric point | 9.51 |
Molecular weight | 25993.48 |
Publications | PubMed=25730766 |
Annotated function |
Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors.
ECO:0000256 RuleBase:RU364151 |
GO - Cellular Component | mediator complex GO:0016592 IEA:InterPro |
GO - Biological Function | transcription coregulator activity GO:0003712 IEA:InterPro |
GO - Biological Process | regulation of transcription by RNA polymerase II GO:0006357 IEA:InterPro |
Binary Interactions |
Repeats | >MDP00050 --------------------------------------------------------------------------- No. of Repeats|Total Score|Length |Diagonal| BW-From| BW-To| Level 2| 55.54| 18| 27| 173| 190| 1 --------------------------------------------------------------------------- 173- 190 (31.67/17.42) KNSLDSLDGD.EPERKKHK 197- 215 (23.87/11.46) KKKKDKKKKDkKDEERKHR --------------------------------------------------------------------------- |
MoRF Sequence | Start | Stop |
1) KHKSEKKEKKKKKDKKKKDKKDEERKHRKTAE 2) RYRYLF | 188 141 | 219 146 |
© 2021 Shailesh Lab
Designed by Dr. Shailesh Lab & Dr. Jitendra K. Thakur Lab