<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00049

Description Uncharacterized protein
SequenceMSAKTSKVLSWYQSTADKRILRRHKIGPPDVHPQEPRQEEDNLSNERLRKGYQVGTTPFEHESLVFNSRSAKLDRLDEAHAKSAALLNLVLHRKGEINANLDKERRKNRETTGAQFATAKAKERAAWFTDLARGKALSQLAKKVPTIKRREEGLDYLCDYRIPSFRALWYLKVTAALTGSPSTAKQKKSISDLFSAEYKDIFVKAIKELTIRMWDVNDLSTCPVYTERWLYISNLSKCAFEDGVIERQDFLNELCDIFSDYFVRRVKNEEKLPQLRVYLLFLTQFLRHINNNLILARRLAHMIAMKLRLYKMEYDEQNNTVTKGSEAFMVLTKCSALRPIIHVLTAVLQNIVIDAPAAVIWNKFKVSTTDKLPFILSQLCGSPLDLLPCAIHELPLPPGKESERFVELLKLRTAEIVRRSQAVQDKWSFNQKEQFAFAKLVNGCLDVIGILDSTDVLEPNILPAVTTRIFNFRSENWAEEVLIRIKLMLHWAVTAEREGSHRAIIVTKVIYQQVLNQQSYMFGPFHMQDIILNYFYTEAPTHGSKYYHQEFASLVTLFIELSRFKLFVHDCFVKELIKSGELDYQRPVMDKFKCESKPPDPITSSLISAQFEDLTPEEPPKPTGLISYKQEEKDEHVYLNGSMSMNDRILIQMPLRQTEEHRSEANQRALVLYGMDDARENHKAEMKKIAKEICKIWQKKIYVQFSEGNEAPSWKQSINSQRIVEILARFRSQTYYDQMMICGWCAESFSDMIRDFILGHCLQMPTSEGLDIICGMFESAQYIYGIFELCEAVTPLLPCAEKVIRSLAADVIPGSMSGQLGYVFVAYICRHWHYFLHSDLAPTITNQLYELIERMIRAHEYPMTSWGRTIAAFVYHSKSQLKKSQLSDIKLHGARDDFRHVFNHGSSSYNGGSRYNALFFKDVFEKKLRFFSYHEYKKRLPSFGQLYNRYSFVINSFIAAKNFMRDHDRLSDLAAFCGHISAQIPALADEWVAAIKALCCTSVSQHTGYGELLAHIDVNDCSTHYPIATFVMLLAGKYAFSVPRLIAELLNNAFPVIMKREQSSFVSGRYNVIGRSEYDCEPGVCLTLLILAQLSCATDEPFHLSEHYVGGTPRIKLLAKCADELMLSMIHWCEMDNVLFPMLSNICILMDTLRTRFKDLDFEPSRIVDSTTYRREYLMIMLKAVQLIICEEDWVTMKMFKIVETNRMEAFNHDRLKQNCLGQQLLRLGIRRRSERDVVRELSVCNGNSKKALIDKLLAVMNMWNMRATLFDLMLMIKEISPEGAQKHAQQSAIAADALMGEIGKCCRDLFTNAHKEGLQLSSAVLGRDFRFRHVTNFWLIALLVRLCPQPNNVPNQFHHMTVSGKFLKEAASMLDTANDSSKERIQQSAWLLSQQPFLNLVLACLKGEDFQPNKDLLVSSLYKQLLDLTSKTKENPALPLMEKFSAEREGLLLRLSLVGGIFKQICQPQHSEGWSHLFFQMMLYGMVSPDKDRILYDSCYDMLSTLMLWTLTDPSTATQQLSEGSEPKFRWPYYSIIIKKLKKEIADQRVPPELRALLQFLPIPKNTISVFAMEPYGAPPATNVQKVSGGAARPPSVSQSTPMTGLRHGRYALHVSEKVKTSSYDFIHAYINEQNSKGGWKWSWFQASKVDRLPCPVQKWVARLLVHKHQLEYQRPNAVINEASDHFLSAPAVETTGEAPPPSASSANTPGTQTPATPTASVVTEATTPGNEEAITSLNSAVSTPTTNDVNMDDTTPEQNRSLSSASNPIVSPRAAVRGGRKRGNVNRQHSAGSRQKRSASRNEPPGPSVTAPFNQTWHGTGPNQAGNVLSQPDSVTYSQHQTQQVSSNAVKDPTKTKIQECINKKRLEAARISAGFPGPSSSQPSTIGPNLSQTTYSEPNFNHHSANNRSMPGDYQSQQPGQGSFVQNAGSHMQTTMLQQQSQPSLDPSQQSQQQMPQQQQIQSNQQGHHQLPAHQQQQSSQQPSGAVPHSMQPQVMQHMQPHHMQQQMPPQQSMQQSHMPSQTMQHPQVPQQPMMQQQMGQSHVQQQRSSNAQGAMGNQQFSQVGGSGQHQSSIGGPMQMGYQGQAHTAQPPQQSQQQPRNTMGQFTSRDGSMSMDYQQGGRGSRQSMQMNQQMGSQGTMGRNTISGNQMNSQGHMGSQHIPDGQQVMGQQIGGHAMGSQQMAHQMGQSSMSGQQYFMQQDQRIMNPPYSQSQYQSNNQF
Length2223
PositionKinase
OrganismAncylostoma ceylanicum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma.
Aromaticity0.08
Grand average of hydropathy-0.457
Instability index49.16
Isoelectric point8.80
Molecular weight251873.65
Publications
PubMed=25730766

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00049
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
            11|     413.40|      34|      34|    1971|    2004|       1
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 1836- 1865 (29.78/ 8.44)	S...V.....TY.SQ.HQTQQVS.......SNAVKDPTKTKIQ...EC.......I.N.
 1873- 1904 (31.37/ 9.26)	..........RI.SA.GFPGPSSS....QPSTIGPNLSQTTYS...EP.......N.FN
 1905- 1946 (29.54/ 8.32)	H...HsannrSM.PGdYQSQQPGQgsfvQNAGS..H.MQTTML...QQ.......QsQP
 1947- 1970 (38.22/12.79)	S...L.....D..PS....QQSQQ....Q....MPQ..QQQIQ...SN.......Q.QG
 1971- 2004 (68.35/28.34)	H...H.....QL.PA.HQQQQSSQ....QPSGAVPHSMQPQVM...QH.......M.QP
 2005- 2036 (46.16/16.89)	H...H..mqqQM.PP.QQSMQQSH....MPSQTMQH...PQVP...Q..........QP
 2039- 2083 (32.87/10.03)	Q...Q.....QMgQS.HVQQQRSS....NAQGAMGNQQFSQVGgsgQHqssiggpM.QM
 2090- 2118 (41.39/14.43)	H...T.....AQ.P....PQQSQQ....QPRNTMGQFTSRD.....GS.......M.SM
 2127- 2157 (36.90/12.11)	S...R.....QS.MQ.MNQQMGSQ....GTMGR..NTISGNQM....N.......S.QG
 2158- 2186 (26.73/ 6.87)	HmgsQ.....HI.PD.GQQVM.GQ....QIGG...HAMGSQQM...A............
 2187- 2210 (32.09/ 9.63)	................HQMGQSSM......SGQ.QYFMQ.QDQ...RI.......M.NP
---------------------------------------------------------------------------
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     543.46|     167|     200|     729|     904|       2
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  729-  904 (277.75/226.73)	RFRS.QTYYDQMMICGWCAESFSDMIRDFILGHCLQMPTSEGLDI..ICGMFeSAQYIYGIFELCEAVTPLlpCAEKVIRS......LA.ADVIPGSMSGQLGyVFVAYICRHWHYFLHSDLAPTITNQLYELIERmiraHEYPMTSwGR..TIAAFVYHSKSQLKKSQLSDIKLHGARDDFRHVFNH
  929- 1107 (265.70/185.93)	RFFSyHEYKKRLPSFGQLYNRYSFVINSFIAAKNFMRDHDRLSDLaaFCGHI.SAQIPALADEWVAAIKAL..CCTSVSQHtgygelLAhIDVNDCSTHYPIA.TFVMLLAGKYAFSVPRLIAELLNNAFPVIMKR....EQSSFVS.GRynVIGRSEYDCEPGVCLTLLILAQLSCATDEPFHLSEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.51|      18|      48|    1470|    1488|       3
---------------------------------------------------------------------------
 1470- 1488 (31.03/25.44)	QHSEGwSHLFFQMMLYGMV
 1521- 1538 (35.48/22.23)	QLSEG.SEPKFRWPYYSII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.56|      27|     430|    1345|    1391|       4
---------------------------------------------------------------------------
 1339- 1376 (33.17/63.46)	W.....liallVRLCPQPNNV.PNQfhHMTVSGKFlKEaasMLD
 1391- 1428 (36.39/14.24)	WllsqqpflnlVLACLKGEDFqPNK..DLLVSSLY.KQ...LLD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.62|      16|      17|    1703|    1718|       5
---------------------------------------------------------------------------
 1703- 1718 (29.04/17.86)	PSAS...SANTPGTQTPAT
 1719- 1737 (20.96/10.55)	PTASvvtEATTPGNEEAIT
 1738- 1753 (23.61/12.95)	SLNS...AVSTPTTNDVNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.90|      18|    1146|     654|     672|       7
---------------------------------------------------------------------------
  654-  672 (27.22/20.68)	PLRQTeEHRSEANQRALVL
 1814- 1831 (36.68/23.69)	PFNQT.WHGTGPNQAGNVL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.07|      19|      56|    1125|    1143|      10
---------------------------------------------------------------------------
 1125- 1143 (38.02/23.55)	LMLSMIHW..CEMDNVLFPML
 1180- 1200 (31.05/17.87)	IMLKAVQLiiCEEDWVTMKMF
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00049 with Med12 domain of Kingdom Metazoa
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