<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00048

Description Uncharacterized protein
SequenceMSAKTSKVLSWYQSTADKRILRRHKIGPPDVHPQEPRQEEDNLSNERLRKGYQVGTTPFEHESLVFNSRSAKLDRLDEAHAKSAALLNLVLHRKGEINANLDKERRKNRETTGAQFATAKAKERAAWFTDLARGKALSQLAKKVPTIKRREEGLDYLCDYRIPSFRALWYLKVTAALTGSPSTAKQKKSISDLFSAEYKDIFVKAIKELTIRMWDVNDLSTCPVYTERWLYISNLSKCAFEDGVIERQDFLNELCDIFSDYFVRRVKNEEKLPQLRVYLLFLTQFLRHINNNLILARRLAHMIAMKLRLYKMEYDEQNNTVTKGSEAFMVLTKCSALRPIIHVLTAVLQNIVIDAPAAVIWNKFKVSTTDKLPFILSQLCGSPLDLLPCAIHELPLPPGKESERFVELLKLRTAEIVRRSQAVQDKWSFNQKEQFAFAKLVNGCLDVIGILDSTDVLEPNILPAVTTRIFNFRSENWAEEVLIRIKLMLHWAVTAEREGSHRAIIVTKVIYQQVLNQQSYMFGPFHMQDIILNYFYTEAPTHGSKYYHQEFASLVTLFIELSRFKLFVHDCFVKELIKSGELDYQRPVMDKFKCESKPPDPITSSLISAQFEDLTPEEPPKPTGLISYKQEEKDEHVYLNGSMSMNDRILIQMPLRQTEEHRSEANQRALVLYGMDDARENHKAEMKKIAKEICKIWQKKIYVQFSEGNEAPSWKQSINSQRIVEILARFRSQTYYDQMMICGWCAESFSDMIRDFILGHCLQMPTSEGLDIICGMFESAQYIYGIFELCEAVTPLLPCAEKVIRSLAADVIPGSMSGQLGYVFVAYICRHWHYFLHSDLAPTITNQLYELIERMIRAHEYPMTSWGRTIAAFVYHSKSQLKKSQLSDIKLHGARDDFRHVFNHGSSSYNGGSRYNALFFKDVFEKKLRFFSYHEYKKRLPSFGQLYNRYSFVINSFIAAKNFMRDHDRLSDLAAFCGHISAQIPALADEWVAAIKALCCTSVSQHTGYGELLAHIDVNDCSTHYPIATFVMLLAGKYAFSVPRLIAELLNNAFPVIMKREQSSFVSGRYNVIGRSEYDCEPGVCLTLLILAQLSCATDEPFHLSEHYVGGTPRIKLLAKCADELMLSMIHWCEMDNVLFPMLSNICILMDTLRTRFKDLDFEPSRIVDSTTYRREYLMIMLKAVQLIICEEDWVTMKMFKIVETNRMEAFNHDRLKQNCLGQQLLRLGIRRRSERDVVRELSVCNGNSKKALIDKLLAVMNMWNMRATLFDLMLMIKEISPEGAQKHAQQSAIAADALMGEIGKCCRDLFTNAHKEGLQLSSAVLGRDFRFRHVTNFWLIALLVRLCPQPNNVPNQFHHMTVSGKFLKEAASMLDTANDSSKERIQQSAWLLSQQPFLNLVLACLKGEDFQPNKDLLVSSLYKQLLDLTSKTKENPALPLMEKFSAEREGLLLRLSLVGGIFKQICQPQHSEGWSHLFFQMMLYGMVSPDKDRILYDSCYDMLSTLMLWTLTDPSTATQQLSEGSEPKFRWPYYSIIIKKLKKEIADQRVPPELRALLQFLPIPKNTISVFAMEPYGAPPATNVQKVSGGAARPPSVSQSTPMTGLRHGRYALHVSEKVKTSSYDFIHAYINEQNSKGGWKWSWFQASKVDRLPCPVQKWVARLLVHKHQLEYQRPNAVINEASDHFLSAPAVETTGEAPPPSASSANTPGTQTPATPTASVVTEATTPGNEEAITSLNSAVSTPTTNDVNMDDTTPEQNRSLSSASNPIVSPRAAVRGGRKRGNVNRQHSAGSRQKRSASRNEPPGPSVTAPFNQTWHGTGPNQAGNVLSQPDSVTYSQHQTQQVSSNAVKDPTKTKIQECINKKRLEAARISAGFPGPSSSQPSTIGPNLSQTTYSEPNFNHHSANNRSMPGDYQSQQPGQGSFVQNAGSHMQTTMLQQQSQPSLDPSQQSQQQMPQQQQIQSNQQGHHQLPAHQQQQSSQQPSGAVPHSMQPQVMQHMQPHHMQQQMPPQQSMQQSHMPSQTMQHPQVPQQPMMQQQMGQSHVQQQRSSNAQGKRSYSHLVRYPVQQQLQEQWAISSSPKLVDQVNTSLR
Length2094
PositionKinase
OrganismAncylostoma ceylanicum
KingdomMetazoa
LineageEukaryota> Metazoa> Ecdysozoa> Nematoda> Chromadorea> Strongylida> Ancylostomatoidea> Ancylostomatidae> Ancylostomatinae> Ancylostoma.
Aromaticity0.09
Grand average of hydropathy-0.404
Instability index48.82
Isoelectric point8.82
Molecular weight238083.86
Publications
PubMed=25730766

Function

Annotated function 
GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00048
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No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             6|     281.86|      40|      49|    1947|    1986|       1
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 1854- 1887 (41.41/20.25)	.DPT.......KTKIQECIN...KKRLEAA...........RISA..GFPGPSSSQPS
 1889- 1923 (49.22/25.71)	IGPN......lSQTTYSEPN...FNHHSAN...N....R..SMPG..DYQ...SQQPG
 1924- 1947 (29.68/12.06)	.......................QGSFVQNAGSH....M..Q.TT..MLQQQS..QPS
 1948- 1987 (78.29/46.01)	LDPS.......QQSQQQMPQ...QQQIQSNQQGH....H..QLPA..HQQQQSSQQPS
 1994- 2037 (56.85/31.04)	MQPQvmqhmqpHHMQQQMPP...Q...QSMQQSH........MPSqtMQHPQVPQQPM
 2038- 2074 (26.40/ 9.76)	M..........Q...QQMGQshvQQQRSSNAQGKrsysHlvRYPV..QQQLQ......
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     543.46|     167|     200|     729|     904|       2
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  729-  904 (277.75/247.44)	RFRS.QTYYDQMMICGWCAESFSDMIRDFILGHCLQMPTSEGLDI..ICGMFeSAQYIYGIFELCEAVTPLlpCAEKVIRS......LA.ADVIPGSMSGQLGyVFVAYICRHWHYFLHSDLAPTITNQLYELIERmiraHEYPMTSwGR..TIAAFVYHSKSQLKKSQLSDIKLHGARDDFRHVFNH
  929- 1107 (265.70/202.93)	RFFSyHEYKKRLPSFGQLYNRYSFVINSFIAAKNFMRDHDRLSDLaaFCGHI.SAQIPALADEWVAAIKAL..CCTSVSQHtgygelLAhIDVNDCSTHYPIA.TFVMLLAGKYAFSVPRLIAELLNNAFPVIMKR....EQSSFVS.GRynVIGRSEYDCEPGVCLTLLILAQLSCATDEPFHLSEH
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.51|      18|      48|    1470|    1488|       3
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 1470- 1488 (31.03/21.38)	QHSEGwSHLFFQMMLYGMV
 1521- 1538 (35.48/18.68)	QLSEG.SEPKFRWPYYSII
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      73.62|      16|      17|    1703|    1718|       4
---------------------------------------------------------------------------
 1703- 1718 (29.04/16.85)	PSAS...SANTPGTQTPAT
 1719- 1737 (20.96/10.02)	PTASvvtEATTPGNEEAIT
 1738- 1753 (23.61/12.26)	SLNS...AVSTPTTNDVNM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     141.94|      29|     209|    1548|    1610|       5
---------------------------------------------------------------------------
 1582- 1610 (50.95/69.76)	ATNVQKVSGGAARPPSVSQSTPMTGLRHG
 1757- 1781 (37.74/ 8.17)	.TPEQNRSLSSASNPIVS...PRAAVRGG
 1793- 1821 (53.25/15.77)	AGSRQKRSASRNEPPGPSVTAPFNQTWHG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      69.07|      19|      55|    1125|    1143|       6
---------------------------------------------------------------------------
 1125- 1143 (38.02/23.21)	LMLSMIHW..CEMDNVLFPML
 1180- 1200 (31.05/17.65)	IMLKAVQLiiCEEDWVTMKMF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     222.43|      71|    1145|     159|     273|       7
---------------------------------------------------------------------------
  159-  252 (97.90/123.46)	DYRIPSFRALWYLKVTAALTGSPStakqkkSISDLFsaEYKDIFVKAIKElTIRMWD.VNDLSTCPVYTERWLyisnLSKcafedgvierQDFLN
 1329- 1400 (124.54/62.82)	DFRFRHVTNFWLIALLVRLCPQPN......NVPNQF..HHMTVSGKFLKE.AASMLDtANDSSKERIQQSAWL....LSQ..........QPFLN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     141.33|      47|     951|     447|     499|       8
---------------------------------------------------------------------------
  447-  499 (67.28/74.61)	VIGILDSTDvLEPN...ILPAVTTRIFNFRSENWAEEVLiriKLMLHWavTAEREG
 1402- 1451 (74.05/58.72)	VLACLKGED.FQPNkdlLVSSLYKQLLDLTSKTKENPAL...PLMEKF..SAEREG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      92.90|      25|    1146|     563|     587|      17
---------------------------------------------------------------------------
  563-  587 (45.28/34.00)	RFKLFVHDCFVKELIKSGELDYQRP
 1653- 1677 (47.62/36.22)	RLPCPVQKWVARLLVHKHQLEYQRP
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Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00048 with Med12 domain of Kingdom Metazoa
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