<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00012

Description Mediator of RNA polymerase II transcription subunit 5
SequenceMDGRVIRGVQRAALEQWTEFIAKSLAHRIDPEKFESYVPFLQAKHPLPPVAVADLFLRPQPHNHESLDPRVPRYLQVLSSLNYIDTPSILKALYKYSTSRGHSREAGQLPDAEDQTSNFPRWESSYAAEEVMFYRLTKSVAQGTAIQNTGTGLEIANVMAKWIALFTDAATAFTVDVMGQLHNSQVREEMESARAAFVALLLGVCENQVVLKSLSKPEAQEIRKALSESLANFVPTIMQSAGPIATRLDMFRTSTLAGFEPVDEQKNKSNAEIEDLFDSTVALENFVVSELPIVNSRAGLYIYLNAALVGRPLIDDLAIFNYLNNRYQGDVQSTTVDLILVSFDILANAASRNEGHQAAHLLRSFLMNKLPILIESLSKHMYGPVNAEYCITEALSRVDTTTFPTLSSMFDETRSNNPFTDSVREDFCWACCLHGLLRESSIETLLGETPYSSLPASGRYVKENLVAECLADPERMQALIGELDSKEGNAGAVCQALTEVMGQLCRNKETMSLKLLCSQLAQKPLSLDVMLMFEKPATILHPLCDLLDNWKYDEDQGEYQPVYEEFGSILLLVMAFAYRYGLSASDMGIISSDSFVARLLGHGHQSRTLEELSDQEKGHLDGWIHGLFDSEAGGLGDELMSSCPPQDFYLLVSTLFHNIVLAFSTGHLTEESLRGGIEYLVDTFLLPSLVIAITSLANSLWVERPDCQKAIVRVLNSVLAPTSISNEAQAMLSSVMNIVAKPLEHSLRAYQRSDPKSQEVEPLLKAIKDSIPLSRRTGAADHQELDAWSMGGFSNSIRQTLQQLVQWSIHPTMDRMPPAYTHRQMLVAMKLLGAKRLLQLLYEDIRQQTETGSGSIIYDVATALVCAPDVVNTPSNPINFIDNSGNVPAPVQRKLTLREVLKSDAEECKKLQKVDMNLAEIVVRLYRKVETQMAVSQAEVIQADTMLQTDLGLSLDAGAGSLDDAMAAAAANVAQGDGMSVDNVSLDLGLGGVGGDLGLGGSSNNGGGSLDLGADDLFSGLGAGDDFQWDNMDLS
Length1035
PositionTail
OrganismColletotrichum fioriniae PJ7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum acutatum species complex.
Aromaticity0.07
Grand average of hydropathy-0.091
Instability index41.92
Isoelectric point4.80
Molecular weight113554.72
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00012
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      66.45|      20|      21|     985|    1004|       1
---------------------------------------------------------------------------
  961-  980 (30.26/15.10)	SLDDAMAAAAANVAQGDGMS
  985- 1004 (36.19/19.45)	SLDLGLGGVGGDLGLGGSSN
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      76.90|      22|      25|     230|     251|       2
---------------------------------------------------------------------------
  230-  251 (39.24/26.15)	LANFVPTIMQSAGPIATRLDMF
  256-  277 (37.66/24.80)	LAGFEPVDEQKNKSNAEIEDLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|      89.51|      22|      22|     462|     483|       5
---------------------------------------------------------------------------
  424-  454 (23.68/13.25)	RE.DFCwACCLHGLLRessIETLLGEtpyssL
  462-  483 (39.23/27.10)	KE.NLV.AECLADPER...MQALIGE.....L
  486-  504 (26.60/15.85)	KEgNAG.AVCQALTEV...M....GQ.....L
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      49.08|      14|      25|     507|     520|       7
---------------------------------------------------------------------------
  507-  520 (23.80/14.72)	NKETMSLKLLCSQL
  534-  547 (25.28/16.09)	EKPATILHPLCDLL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      46.69|      14|      27|     649|     662|       8
---------------------------------------------------------------------------
  649-  662 (23.37/16.05)	YLLVSTLFHNIVLA
  679-  692 (23.32/16.01)	YLVDTFLLPSLVIA
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      44.34|      15|      30|     725|     748|       9
---------------------------------------------------------------------------
  725-  739 (22.50/ 7.13)	SNEAQAMLSSVMNIV
  757-  771 (21.84/24.25)	SQEVEPLLKAIKDSI
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      68.54|      19|      25|     850|     868|      10
---------------------------------------------------------------------------
  850-  868 (32.87/21.28)	ETGSGSIIYDVATALVCAP
  872-  890 (35.68/23.72)	NTPSNPINFIDNSGNVPAP
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00012 with Med5 domain of Kingdom Fungi
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