<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00007

Description Mediator of RNA polymerase II transcription subunit 13
SequenceMDTSEYDTNTLLNNNISTINYRVYEPSPEQASSFPSIAADVETELRTLNHIVYYDANRRVVWYFHIPGKDAESGDDTPRVLDSSVSVAGATLLMVDEGSFEPISLFKGRAQGQQASNTPTSSSSSNSALDLSLRNPQMGNSGPPSSSDPDSKPPSAGALDSKGTGSVPIKEAYEQFITAVLSTTSASFCNRVSAIPLNHRTVLLPSKVTRDGQTERAQDTESAVVGTFRVYLTTTGALVISLSLSCCEGLLSVNEPSSPSQLALGSQILAAPFGVLANYQGFVGGGLSYPEIGLGQTPDAQLWRNADARSSQWRETCIKILQSRGLSPALLQSCPWIALQMLRRKPGESKSEGKTTPLSSAVATVSWPAVLCFRKKSVMLARSNGLGDSVLLAQDETSDFLNEARTWFQLGADRDEKVTKRKKEREAAASKEASAAASTHQPNGHSPLGLRRASNAAAAGAMYPTPPDGVQNPLGITPSMDGTTSSPGAPGVTMAVVDIDTTMTDATVHDAPTMHGTLQHDSYADGWHSNEHANEHTNEHANENGKGRADSFTGGDNDDNLFGDMGPDMFGDTDITDADFNFFDEEGDDLDLSGLPDLGMPDGPPMPAVLPVSMPEPAKLMLPPVEDTKPEPSPPIFTKPELKHARSTLMDEGKQRSNTDRAGGMKRESSPFDPDIVYKRVRASLADIRSAPQSTPARKGSIFDSVDFDPVLPLVNKKYEQGGRFDCKPTLQGLPQESSNQSLHQGPPTTDYLRRHGKGRKPLKQPEHTNALIRTITGNLENSSLIASPGKGDDLASDADDISLVSDQDDSSTSEDEPTSPFKSSIRRLNLDDDVASHVTSLRDIESVEDSDPTLALDLPKLAKAEASEMLITRYFEDAESLPIHLSLPDEDTITIAQIVTEQAVTGNLRIRDAHANTLNSAIIPETRRQLSSLGRTALQALREVIPACLGDFNICNFKGVVEIPDVPLLGPPNRLHPRPVNPRDNNAEPPKPNNLFQIPAPHMELRRAEARLSVLPASVQFWESLGLGPAQGTKDVNVVCVFPHWDGMSDVAAAFLDRMRNVYELLKLGSFERLATSSKVADGLLPYEVDKIATSPGTVSPHIVAGLGDRMEALNQGLISANASEKNYVIYFVYPPDHPGSIVEACTAFQQLFEMHKRTLTDRRQTPVNELVLQLVPLDFLTSSTGIVEPTPSDAIKLAIETYDRCTLFGGPMPSPAIMLEQSLPRGIDFKLSNPSSSSLMHENTCIHIAYAQSIDERWITAAWTDNRGCQQMTASYNLGRKGKALSTSLNDVYHEIWETTHDLISKWKVHWRVIISKCGFMDAQEIGFWQGLAQTESVATVSLTLISVDTNPSMQLVPPAIKVPATTSSAFYTTPVSTPQASIVSPEQSGTPATPMKENTTSAATPGGTPGDGNADPVEGDAILLDVTDQTWGAVLAHRLSNSSSLGELSPALISGYLVKRGGTKLEDPPVVLEVSIVHADNNPRMYEPLMREMLTYFRGLGTLARARGVVDRGTDIRPWHIAAAEKGVRALYLLM
Length1538
PositionKinase
OrganismColletotrichum fioriniae PJ7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum acutatum species complex.
Aromaticity0.06
Grand average of hydropathy-0.361
Instability index45.86
Isoelectric point5.05
Molecular weight166212.49
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00007
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     102.42|      32|      33|     788|     819|       1
---------------------------------------------------------------------------
  788-  819 (55.83/28.89)	SPGKGD..DLASDADDISLVSDQDDSSTSED.EPT
  820-  854 (46.59/23.00)	SPFKSSirRLNLDDDVASHVTSLRDIESVEDsDPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      90.20|      30|      34|     631|     663|       2
---------------------------------------------------------------------------
  631-  663 (45.84/41.77)	EPSPpiFtKPEL..KHARSTLMD.EGKQRSNTDRAG
  668-  700 (44.36/27.98)	ESSP..F.DPDIvyKRVRASLADiRSAPQSTPARKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     184.87|      53|     607|      95|     165|       3
---------------------------------------------------------------------------
   81-  145 (75.20/56.72)	LDSSVSVAGAtllmVDegsFE.........PI.SLF.KGRAQGQQASNTPTSSSSSN..SALDLSLRnpqmgNSGPPS
  149-  200 (51.60/31.17)	PDSKPPSAGA...........ldskgtgsvPI.K...EAYEQFITAVLSTTSASFCNrvSAIPLNHR...........
  706-  749 (58.07/22.66)	..............VD...FD.........PVlPLVnKKYEQGGRFDCKPTLQGLPQ..ESSNQSL......HQGPPT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     124.59|      28|     607|     603|     630|       4
---------------------------------------------------------------------------
  603-  630 (56.27/34.44)	GPPMPAVLPVSMPEPAKLMLPPVEDTK...P
 1014- 1035 (28.23/13.03)	.....SVLPASVQFWESLGLGPAQGTK....
 1211- 1236 (40.09/22.08)	GGPMPS..PAIMLEQS...LPRGIDFKlsnP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     157.44|      51|     609|     287|     343|       6
---------------------------------------------------------------------------
  287-  343 (84.42/77.15)	LSYPE...IGLGQTPDAQL....WRNADARSSQWRETCIKilQSRglspALLQSCPWIALQMLR
  886-  943 (73.03/50.45)	LSLPDedtITIAQIVTEQAvtgnLRIRDAHANTLNSAIIP..ETR....RQLSSLGRTALQALR
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      77.40|      24|     609|     475|     498|       7
---------------------------------------------------------------------------
  475-  498 (43.79/23.16)	GITP.SMDGTTSSPG..APGVTMAVVD
 1084- 1110 (33.60/15.98)	GLLPyEVDKIATSPGtvSPHIVAGLGD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00007 with Med13 domain of Kingdom Fungi
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