<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00004

Description Mediator of RNA polymerase II transcription subunit 14
SequenceMENGGLKGTHSNHDRNLKVNGVNGGTMEGQPNKGKAPADNPGAGNMANGLSGGNAQNDSQGKQQSQMSTGLTLQQKPRMNDLPEEIVHITQGYIPLSTIVARLAQHTHEELQKTVIEMGSIKWAPPAVNGNTPHGSDAPDDMSEGNKRKKMLMIKFAQDAHSKWVKALVITDWSKNAEAVSKLIDIKAHIDSKRMLYDYSQDLLIDLKRSLDNARLPNPDLKTALQVLTTGEASWIPEPGYIPPPPLTAEEQLKWIDDLNTMLSLRLNLEDYDKIPHQFKNYSIQSGRVTFVVKGEFEVDLTIADEDFTQQFWFIDFRFAFSPSSSKLSDALVSFLEAHVNEILGKEGLEGCYRFLHEFVLTHKISELRRQAIELSRSTWTGTLMVEPLNRALALQYWTTRYGANGPKSWVMIAVNSAKKTNGQTDSKHSSRLVARWYRDNKEVKDVLLPFDVDNLCAEDLLKTAVARHVEHILSSIHTKLLSFPRFINRESSMTLTISQTEPMESSLSMQLSPRDNVTLLIQPITGYAAIKPHAKYTLQGESRLNYGGKDPAEDGVTCLENIRWGYFIEECSRRGRSVGWKTCKSPLGGEDIKQIIRTREAFQTIFMQRQSLDQNWFVMVSLSLSGDEWWLLDIDRNTPTRPIKFHTKLQLTRGQPDLDDAFWSHLTLFVTGIVQQATDLEHLHRGKIQYLMKESTNYALPQQVRLPSLVIKLSQILGSSETGAQDGSKDTSRQSSKQDSSWAQDQVEVKFKGLQTRPTAAQGQDGNAPSAVEILENAELNTIVDAIVRVKDKTKFALLKGRIDRNVSFSPKKGEFIFRIRYLVGRPILETLTTHVKSIDRLVGFLEAMSKARGSVKCERVSLQQVVFTYSDITMPGESDQTLKPKRWRVSLDLAKSQIRMSLEKGNPHARVLDLLTTLVNTQDGLRVLIFYMPILLPVLRTLESIESKWEPLETTNQGRVEIFTRSIDWIALRYTLPSPTGEPRVLVLEIRSRMRRNEMWWNFTRATQGAVAPDEEFNKILKGIWESHGNGWRGLRTSAASRPGPSTMELLTKLDDLVRAYAVTGDVSNAPSTEGQPTQTSQTTSTNQSFGTQPTSVSQGSNRTGGGSKQAPLVLD
Length1118
PositionTail
OrganismColletotrichum fioriniae PJ7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum acutatum species complex.
Aromaticity0.07
Grand average of hydropathy-0.461
Instability index42.14
Isoelectric point8.68
Molecular weight125462.11
Publications









Function






Annotated function

Component of the Mediator complex, a coactivator involved in
the regulated transcription of nearly all RNA polymerase II-dependent
genes. Mediator functions as a bridge to convey information from gene-
specific regulatory proteins to the basal RNA polymerase II
transcription machinery. Mediator is recruited to promoters by direct
interactions with regulatory proteins and serves as a scaffold for the
assembly of a functional preinitiation complex with RNA polymerase II
and the general transcription factors. 


ECO:0000256	RuleBase:RU365082

GO - Cellular Component
mediator complex	GO:0016592	IEA:UniProtKB-UniRule

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:UniProtKB-UniRule

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats

>MDP00004
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     433.98|     143|     151|     604|     754|       1
---------------------------------------------------------------------------
  604-  754 (221.35/175.21)	QTIFMQRQSLDQNWFVMVSLsLSGDEwwlLDIDRNTPTRpIKFHTKLQLTRGQPDLDDAFWSHLTLFVTGIVQQATD..LEHL..HRGKIQYLMK..ESTNYAlPQQVRLPSlvIKLSQILGSSETGAQDGSKDTSRQSSKQDSS..WAQDQVEVKF.KG
  756-  907 (212.63/140.39)	QTRPTAAQGQDGNAPSAVEI.LENAE...LNTIVDAIVR.VKDKTKFALLKGRIDRNVSFSPKKGEFIFRIRYLVGRpiLETLttHVKSIDRLVGflEAMSKA.RGSVKCER..VSLQQVVFTYSDITMPGESDQTLKPKRWRVSldLAKSQIRMSLeKG
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      53.92|      18|     151|     181|     199|       4
---------------------------------------------------------------------------
  150-  173 (21.27/ 6.59)	KMLMIKfaqdAHSKWVKALVitDW
  182-  199 (32.65/20.14)	KLIDIK....AHIDSKRMLY..DY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      62.58|      20|     365|      48|      67|       6
---------------------------------------------------------------------------
   20-   46 (26.04/13.56)	NGVNGGTMEGQpNKGKAPAdnpgagNM
   48-   67 (36.54/22.03)	NGLSGGNAQND.SQGKQQS......QM
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      63.01|      18|      18|     219|     236|       7
---------------------------------------------------------------------------
  219-  236 (29.35/17.75)	PDLKTALQVLTTGEASWI
  239-  256 (33.67/21.53)	PGYIPPPPLTAEEQLKWI
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00004 with Med14 domain of Kingdom Fungi


     
       
      
        
        
        


      
      
   
   

      

      














Intrinsically Disordered Regions








IDR SequenceStartStop




1) MENGGLKGTHSNHDRNLKVNGVNGGTMEGQPNKGKAPADNPGAGNMANGLSGGNAQNDSQGKQQSQMSTGLTLQQKPRMNDLPEEIV
2) TGDVSNAPSTEGQPTQTSQTTSTNQSFGTQPTSVSQGSNRTGGGSKQAPLVLD
1
1066
87
1118










Molecular Recognition Features






MoRF SequenceStartStop




NANANA