<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Detailed information on MDP00001

Description Transcription mediator subunit Med12
SequenceMGVQPRPPQQRTLSSSGLSVQRPTQQRTLSAQYLPQSPVRKDNLIDLTGDANDAAVAQNRYGTLPRRGGSRLKLELSNEAMLAQHGVSESPKTLTPSRLIPKNETSNLTDMSSPASAKGQPVDADNPPMPMPKRRPRFVVPAAVKDAPAPVMAVKKDGRPKPYHIETPNIAPRYAPFSKPRPDAAAKPGSGFGGSSSGARDIPDMGHADFFPWTGNHPEDQYTESIIKNGYYDKQPQASVETQSAKAALFPALKHKSGLNLLSNIFIGVLNQRKLNGQISSPSTFKPPPRVTLTDTKREMWLRDLANPSISLRRLSRTIPHGIRGKVLLDHCLNKNVPTERAVWLVKCVGANEIRAFKRKGNGPGPFVLGGEAKWLRDWTVFVEQFVEGVSTAFGDNDWKAKVQYAIRLATHLYAEQLLDRDHYMDWLVSGLENSTQSKLPMWILTTQIYWKDLLRLRRYGRRLVNALLSHLNTIHNDPDRDILTQLSTRLTSLLTPLLSAYSDNFVSPATWFKYRDALLASIPIDNDFAQNTFKWINVRNEQLVASASNSQPANRQILVKHLDTSFMSLYSPDLATQCWAVSEDKGMIVRTLLEWCTSPHRPGTAKVYITACLLRAWAAAGVDVTTAILEFLSANPPTETRSKRVFHQLVSEIVRSGDFQLQGYIFWLIARGGLREPADTEAEGSCATRLLVDLPLHALNSSAQATRASLLRRASYDVNDEAEDINTALKCIQHVMGLPLPPGDPMLQRKPVPVGKLCRLISNSNRALQTEVGARLLQIFTKEIIMTKNGPQVSPAMFNFARAVLEAASDYSVLVEIVKVVSRASNPEILASCADTFNVHLPIFAALGVAKELFDALMERLKAVSDEQGPAARPLLASLANLSTLIPGYTNTAVYLRQQLHQCDRNNPIDACSPVSDNMTAQLQDAEGELHEEIEKLLTSGTSVDRPTMDRLFQTVVGRLESCWLKSADRQRAYSALLGRLRIFDAQHFDVRMTDWVHHISALKTRPALENIYPLLISMGCLTLPIILTTTSVEAGRIGLNPSTPPNSTTTYMQEVLSLTTMPLPAKTALTPEETYRFYIQQRVAPRQNHKDMVYLVRNALVEFSRLQEVVEFSTLPLANPEIKDTALQLLKFLVLRDPPSVVQALGIKNPEPALTSLFAQITTKLLLPDAGDDSPLTFETVLELANEFTLPFCQLKLSVGLAADSTTSPGGGEQALTQFDMFSRAMDRAVSANNVMWTSMLPYLSEDITEHLKKQAHLRFLGLFPSNKNPPAADPLSQESTQLAGSLLSVVEAILRGRPPVRTSQLTSGMVEKLAELWELLATDDINKRDLRASILRYWLPALLRFITLHTTANEPAPVATQPQAANNMKPPANAAVFEIRARILIVLSGLTLELDNVAFQDAQNGRPLGQQVFDLALLLVDTLPDDVRLQCVRVLLTGGTMQNPASSDARLRYLFSHMPPPTEQFVLAHRQQSTTQPNGPQRIKMPISMQGTDKLTPFIYRKWEMLSEPTPNVGENDTALSLTLFEAIKIQ
Length1534
PositionKinase
OrganismColletotrichum fioriniae PJ7
KingdomFungi
LineageEukaryota> Fungi> Dikarya> Ascomycota> Pezizomycotina> Sordariomycetes> Hypocreomycetidae> Glomerellales> Glomerellaceae> Colletotrichum> Colletotrichum acutatum species complex.
Aromaticity0.07
Grand average of hydropathy-0.226
Instability index44.94
Isoelectric point8.83
Molecular weight169958.01
Publications









Function






Annotated function

Component of the SRB8-11 complex. The SRB8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The SRB8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.


Component of the srb8-11 complex. The srb8-11 complex is a
regulatory module of the Mediator complex which is itself involved in
regulation of basal and activated RNA polymerase II-dependent
transcription. The srb8-11 complex may be involved in the
transcriptional repression of a subset of genes regulated by Mediator.
It may inhibit the association of the Mediator complex with RNA
polymerase II to form the holoenzyme complex.



GO - Cellular Component
mediator complex	GO:0016592	IEA:InterPro

GO - Biological Function
transcription coregulator activity	GO:0003712	IEA:InterPro

GO - Biological Process
regulation of transcription by RNA polymerase II	GO:0006357	IEA:InterPro









Interaction





Binary Interactions











Repeat regions





Repeats
>MDP00001
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             3|     214.41|      54|     565|     854|     924|       1
---------------------------------------------------------------------------
  311-  338 (31.68/ 7.63)	..........SLRRLSRTIPHGIRGKVLLD...HCLNKNVP...............
  869-  924 (88.80/64.69)	QGPAARPllASLANLSTLIPGYTNTAVYLRQQLHQCDRNNPIDACSPVSDNMTAQL
 1445- 1498 (93.93/42.56)	QNPASSD..ARLRYLFSHMPPPTEQFVLAHRQQSTTQPNGPQRIKMPISMQGTDKL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      57.23|      16|     565|     417|     433|       2
---------------------------------------------------------------------------
  417-  432 (30.31/24.55)	QLLDRDHYMDWLVSGL
  453-  468 (26.92/14.70)	DLLRLRRYGRRLVNAL
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     302.95|     101|     365|     596|     866|       3
---------------------------------------------------------------------------
  478-  583 (149.33/252.38)	DPDRDILTQLSTRLTSLLT.PLLSAYSDNFVSPAtWFKYRDALLASIPiDNDFAQNTFKWIN.VRNEQLVASASNSQPANRQILVkHLDTSfMSLYSPdLATQCWAVS
  764-  866 (153.61/80.74)	NSNRALQTEVGARLLQIFTkEIIMTKNGPQVSPA.MFNFARAVLEAAS.DYSVLVEIVKVVSrASNPEILASCADTFNVHLPIFA.ALGVA.KELFDA.LMERLKAVS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      60.86|      17|     400|    1118|    1134|       5
---------------------------------------------------------------------------
 1118- 1134 (30.01/17.96)	PLANPEIKDTALQLLKF
 1512- 1528 (30.84/18.67)	PTPNVGENDTALSLTLF
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      48.32|      13|      15|       1|      14|       7
---------------------------------------------------------------------------
    1-   14 (23.00/17.05)	MGVQpRPPQQRTLS
   18-   30 (25.31/13.11)	LSVQ.RPTQQRTLS
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     112.99|      33|      34|     100|     132|       8
---------------------------------------------------------------------------
   64-   96 (54.25/30.24)	LPRRGGSRLKLELSNEAMLAQHGVSESPKTLTP
  100-  132 (58.74/33.36)	IPKNETSNLTDMSSPASAKGQPVDADNPPMPMP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.09|      18|      34|     396|     414|       9
---------------------------------------------------------------------------
  396-  414 (28.15/25.09)	DNDWKAKVQYAIrLATHLY
  433-  450 (32.94/23.64)	ENSTQSKLPMWI.LTTQIY
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      84.11|      26|     365|     596|     625|      10
---------------------------------------------------------------------------
  596-  625 (41.39/33.46)	WCTSPHRpgtAKVYiTACL..LRAWAAAGVDV
  965-  992 (42.72/22.33)	WLKSADR...QRAY.SALLgrLRIFDAQHFDV
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|     166.33|      51|      85|    1258|    1309|      11
---------------------------------------------------------------------------
 1258- 1309 (81.73/51.92)	AHLRFLGLFPSNKNPPAADPLSQESTQLAGSLLSVVEAIlRGRPPVRTSQLT
 1344- 1394 (84.59/49.82)	ALLRFITLHTTANEPAPVATQPQAANNMKPPANAAVFEI.RARILIVLSGLT
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      61.14|      20|      23|     135|     157|      12
---------------------------------------------------------------------------
  135-  157 (31.27/20.69)	RPRfvvPAAVKD...AP..APVMAVKKD
  159-  183 (29.87/12.82)	RPK...PYHIETpniAPryAPFSKPRPD
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      65.33|      21|     473|     674|     696|      15
---------------------------------------------------------------------------
  674-  696 (33.57/23.54)	GLR..EPADTEAEGSCATRLLvdLP
 1148- 1170 (31.76/16.19)	GIKnpEPALTSLFAQITTKLL..LP
---------------------------------------------------------------------------
---------------------------------------------------------------------------
No. of Repeats|Total Score|Length  |Diagonal| BW-From|   BW-To|   Level
             2|      56.07|      15|      75|     287|     304|      16
---------------------------------------------------------------------------
  287-  304 (25.77/27.73)	PPPRVTLTDTKremWLRD
  364-  378 (30.30/21.38)	PGPFVLGGEAK...WLRD
---------------------------------------------------------------------------




































Explaination for Stockholm format
  The  "Stockholm" format is a system for marking up features in a multiple alignment. These mark-up annotations are preceded by a 'magic' label, of which there are four types. The Stockholm format is used by HMMER, Pfam, and Belvu. Mark-up lines include any characters except whitespace. Underscore ("_") is used instead of space. 

 #=GR (seqname) PP (Generic per-Sequence AND per-Column markup, exactly 1 char per column) where PP is Posterior Probability  [0-9*], (0=0.00-0.05; 1=0.05-0.15; *=0.95-1.00) 
 
 #=GC PP_cons line is Stockholm-format consensus posterior probability annotation for the entire column.  It’s calculated simply as the arithmetic mean of the per-residue posterior probabilities in that column.  This should prove useful in phylogenetic inference applications, for example, where it’s common to mask away non confidently aligned columns of a multiple alignment. The PP_cons line provides an objective measure of the confidence assigned to each column.
 
 #=GC RF line is Stockholm-format reference coordinate annotation, with an x marking each column that the profile considered to be consensus.





Alignment of MDP00001 with Med12 domain of Kingdom Fungi
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