PPepDB-ID	"Peptide Name"	PMID	"Plant source"	"Plant Family"	"Peptide Family"	"Peptide function"	"Peptide function description"	"Activity against"	Sequence	"Sequence Length"	Validation	"Avg. Molecular wt(Da)"	"Monoisotopic molecular wt(Da)"	pI	Method	"Additional information"
PPepDB_4403	CONA_CANGL	--NA--	"Canavalia gladiata"	Fabaceae	--NA--	Signaling-peptide	"3D-structure; Antiviral protein; Calcium; Direct protein sequencing; Glycoprotein; Hemagglutinin; Lectin; Manganese; Metal-binding; Mitogen; Signal | Concanavalin-A precursor (Con A)."	--NA--	AKWNMQNGKVGTAHIIYNSVGKRLSAVVSYPNGDSATVSYDVDLDNVLPELILQGDATTGTDGNLELTRVSSNGSPQGSSVGRALFYAPVHIWESSAVVAMAISKKSSLFLPIFTFITMFLMVVNKVSSSTHETNALHFMFNQFSKDQKDRNSTTIDFNAAYNADTIVAVELDTYPNTDIGDPNYPHIGIDIKSVRSKKTSFDATFTFLIKSPDSHPADGIAFFISNIDSSIPSGSTGRLLGLFPDANVIWVRVGLSASTGLYKETNTILSWSFTSKLKSNEIPDIATVV	290	"Experimental evidence at protein level"	31421.39	31401.9	5.65	--NA--	"FUNCTION:Glucose/D-mannose/rhamnose specific lectin. Has hemagglutinating activity towards rabbit erythrocytes. Has mitogenic activity towards murine splenocytes that is inhibited by glucose. Inhibits HIV-1 reverse transcriptase with an IC(50) of 35uM. Has a potent antiproliferative activity against L1210 leukemia cells in vitro that is not inhibited by glucose. Inhibits translation in cell-free rabbit reticulocyte system with an IC(50) of 2.08uM. Lacks anti-fungal activity against M.arachidicola, B.cenera and F.oxysporum.SUBUNIT:Homotetramer.PTM:The mature chain consists of residues 164-281 followed by 30- 148. To form a mature chain the precursor undergoes further post- translational modification after removal of the signal sequence; cleavage after Asn at positions Asn-148, Asn-163, and Asn-281 is followed by transposition and ligation (By formation of a new peptide bond) of residues 164-281 and 30-148.MISCELLANEOUS:Binds one manganese (or other transition metal) ion and one calcium ion. The metal ions are essential for the saccharide-binding and cell-agglutinating activities.SIMILARITY:Belongs to the leguminous lectin family."