PPepDB-ID	"Peptide Name"	PMID	"Plant source"	"Plant Family"	"Peptide Family"	"Peptide function"	"Peptide function description"	"Activity against"	Sequence	"Sequence Length"	Validation	"Avg. Molecular wt(Da)"	"Monoisotopic molecular wt(Da)"	pI	Method	"Additional information"
PPepDB_4311	RIP1_SAMNI	--NA--	"Sambucus nigra"	Adoxaceae	--NA--	Signaling-peptide	"Direct protein sequencing; Glycoprotein; Glycosidase; Hydrolase; Lectin; Plant defense; Protein synthesis inhibitor; Repeat; Signal; Toxin | Ribosome-inactivating protein SNAI' precursor [Contains: SNAI' A chain,(EC 3.2.2.22) (rRNA N-glycosidase); Linker peptide; SNAI' B chain]."	--NA--	AIDVVTFYVVAFAQNDRSYFFSGSSEVQRENLFVDTTQEDLNFKGDYTSLCLETNPGNNDVSLGDCSVKSASKVDQKWALYGDGTIRVNNDRSLCVTSEGEAARFRYIQLRIQASITDAKEFTPDLLMLSMENKWSSMSSEIQQAQPGGAEHQVGFGRVYIPLGPKSLAQSISSLSTYKSSAGDNKRLARSLLVVIQMVSFAQVVKLLDQRNHPIDVTNFRRLFQLTSVAVLLHGCPTVTKMPAYIIKMPHFLQELRGKVILGSHRAFDLPVLNPESKVSDSDRFVLVRLTNPSRKKVTLKSSNEPIIILKCLGWANQRWVFNTDGTISNPDSKLVMHVDQNDVPLRKIILSHPSGTSNQQWIASTHPAMKVVATILYLVVLAICGLGIHGAHPTHSAPPTVYPSVSFNLTEANSNEYRNPRSGLVLTAPKAAEGTLVSLEKNVHAARQGWIVGNVEPLVTFIVGYEQMSNQQWTFSTDGTIQSLGKCLTTSSSVMIYNCKVVPPESTKWVVSIDGTITVFNGGEDEERCSVVEEVTRRIGGRDGFCAEVKNGDEKDGTPVQLSSCGEQ	569	"Experimental evidence at protein level"	62598.17	62558.81	6.94	--NA--	"FUNCTION:The A chain is responsible for inhibiting protein synthesis through the catalytic inactivation of 60S ribosomal subunits by removing adenine from position 4,324 of 28S rRNA. The B chain binds to cell receptors and probably facilitates the entry into the cell of the A chain; B chains are also responsible for cell agglutination (lectin activity). Agglutination is inhibited by Neu5Ac(alpha2,6)lactose, and N-linked glycoproteins such as fetuin and orosomucoid.CATALYTIC ACTIVITY:Endohydrolysis of the N-glycosidic bond at one specific adenosine on the 28S rRNA.SUBUNIT:Disulfide-linked dimer of A and B chains.DOMAIN:The B chain is composed of two domains, each domain consists of 3 homologous subdomains (alpha, beta, gamma).SIMILARITY:In the N-terminal section; belongs to the ribosome- inactivating protein family. Type 2 RIP subfamily.SIMILARITY:Contains 2 ricin B-type lectin domains."