PPepDB-ID	"Peptide Name"	PMID	"Plant source"	"Plant Family"	"Peptide Family"	"Peptide function"	"Peptide function description"	"Activity against"	Sequence	"Sequence Length"	Validation	"Avg. Molecular wt(Da)"	"Monoisotopic molecular wt(Da)"	pI	Method	"Additional information"
PPepDB_2124	"Cyclotide chassatide C11, Uncyclotide ChaC11"	22467870	"Chassalia chartacea"	Rubiaceae	Cyclotide	"Antibacterial, Anticancer, Cytotoxic, Hemolytic"	"Target site: lipid bilayer; shows 50% Hemolysis against Human erythrocytes at 13.3 µM ; Shown to possess antimicrobial, cytotoxic, and hemolytic activities and the oxidation of two Met residue causes loss of bioactivities, strengthening the importance of the hydrophobic patch for membrane interaction."	"Escherichia coli (MIC: 8.5 µM), Staphylococcus aureus (MIC: >80 µM), Staphylococcus epidermidis (MIC: >80 µM), Human cervical carcinoma HeLa (IC50: 1.2 µM)"	IPCGESCVWIPCISGMFGCSCKDKVCYS	28	"Experimental evidence at protein level"	3016.6	3014.26	6.03	"MS, PcR"	"Synthesis Type : Ribosomal; The compound, however, is also quite toxic (50% hemolysis of human type A blood cells: HL50 13.3 uM). Also TOXIC TO HeLa cells (50% survival: IC50 1.2 uM). This is an uncyclized cyclotide (i.e. uncyclotides). Compared to cyclotides, the C-terminal D/N critical for cyclization is lacking due to a premature stop codon. Surprisingly, this linear form is not only more abundant in the plant but also more active than the circular peptides identified in the same species. ChaC11A is an Met oxidized form of the native peptide identified during purification. This oxidized form lost its activity compared to the native form. APD update 6/21/2012; 4/2015 | Oxidation of Met led to loss of activity"